Role of [18F]FDG PET/CT in the assessment of suspected recurrent ovarian cancer:: correlation with clinical or histological findings
Role of [18F]FDG PET/CT in the assessment of suspected recurrent ovarian cancer:: correlation with clinical or histological findings
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DOI：
10.1007/s00259-006-0260-x
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发表时间：
2007-04-01
影响因子：
9.1
通讯作者：
Lee, Hyo-Pyo
中科院分区：
文献类型：
--
作者：
Chung, Hyun Hoon;Kang, Won Jun;Lee, Hyo-Pyo
目的评价正电子发射断层扫描（PET）和计算机断层扫描（CT）联合应用对疑似复发性卵巢癌患者的诊断价值，并以临床或组织学表现为参考标准。（中位年龄，51岁）的卵巢癌患者接受了原发性肿瘤细胞减灭术，随后接受了含铂联合化疗，对疑似复发患者行[F-18]氟脱氧葡萄糖（FDG）PET/CT检查。在所有患者中，将影像学结果与手术探查或临床随访后的组织学检查结果进行比较，以确定PET/CT在评估疾病状态中的诊断准确性。Fisher精确检验被用来衡量PET/CT的能力，以预测复发lessons.Results 45（58.4%）的77例有记录的复发手术探查或临床随访，而32（41.6%）没有复发肿瘤的证据。在45例复发患者中，27例（60%）经手术活检证实复发。PET/CT与组织学或临床分析之间存在相关性（kappa = 0.894）。PET/CT诊断肺癌的敏感性、特异性、准确性、阳性预测值和阴性预测值分别为93.3%、96.9%、94.8%、97.7%和91.2%。PET/CT修改了19例患者的诊断或治疗计划（24.7%）的患者，导致11例患者使用先前计划外的治疗程序（57.9%）的患者和避免先前计划的诊断程序，结论FDGPET/CT是检测卵巢癌术后复发的一种敏感的监测方法;它有助于决定治疗计划，并可能最终对预后产生有利影响。
Purpose To evaluate the accuracy of integrated positron emission tomography (PET) and computed tomography (CT) for depiction of suspected recurrent ovarian carcinoma after treatment, with use of clinical or histological findings as the reference standard.Methods Seventy-seven women (median age, 51 years) with ovarian carcinoma treated with primary cytoreductive surgery followed by platinum-based combination chemotherapy were included, and [F-18]fluorodeoxyglucose (FDG) PET/CT was performed for suspected recurrence. In all patients, imaging findings were compared with results of histological examination after surgical exploration or clinical follow-up to determine the diagnostic accuracy of PET/CT in the evaluation of disease status. Fisher's exact test was used to measure the ability of PET/CT to predict recurrent lesions.Results Forty-five (58.4%) of the 77 patients had documented recurrence during surgical exploration or clinical follow-up, while 32 (41.6%) had no evidence of recurrent tumour. Of the 45 patients with recurrent disease, 27 (60%) were confirmed to have recurrence by surgical biopsy. A correlation was found between PET/CT and histological or clinical analyses (kappa = 0.894). The overall sensitivity, specificity, accuracy, positive predictive value and negative predictive value of PET/CT were 93.3%, 96.9%, 94.8%, 97.7% and 91.2%, respectively. PET/CT modified the diagnostic or treatment plan in 19 (24.7%) patients, by leading to the use of previously unplanned therapeutic procedures in 11 (57.9%) patients and the avoidance of previously planned diagnostic procedures in eight (42.1%) patients.Conclusion Integrated FDG PET/CT is a sensitive post-therapy surveillance modality for the detection of recurrent ovarian cancer; it aids decisions on treatment plans and may ultimately have a favourable impact on prognosis.