Special features of dermal melanocytes in white Silky chicken embryos
Special features of dermal melanocytes in white Silky chicken embryos
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DOI：
10.1002/ar.20623
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发表时间：
2008-01-01
影响因子：
2
通讯作者：
Faraco, Cloris
中科院分区：
文献类型：
--
作者：
Ortolani-Machado, Claudia;De Freitas, Patricia;Faraco, Cloris
在色素沉着的丝羽乌骨鸡（SK）中，成黑素细胞是从神经管迁移的神经嵴细胞，其向背外侧、靠近外胚层和中腹侧迁移，到达胚胎的内脏区域，以及填充真皮。在这项工作中，我们分析了黑色素细胞谱系细胞的形态和分布在白色SK胚胎在后期的发展阶段（6至19天的孵化）集中在真皮的背部皮肤，以表征这个异位定位的人口。在所有分析阶段均观察到成黑素细胞和未成熟的黑素细胞，其中一些明显增殖，表明种群持续更新的可能性。成熟的、完全分化的黑素细胞是具有许多长的细胞质突起的细长细胞，在表皮中形成网状结构，位于胶原蛋白和弹性纤维层下方，其似乎阻止黑素细胞谱系细胞在这些后期阶段到达表皮。SK鸡是唯一的原鸡品种显示这种安排的真皮黑素细胞。在被羽毛覆盖的区域中观察到的胶原蛋白层下方的黑色素细胞的分布显然与裸露皮肤区域中的结构着色无关。SK中这种保守性状的其他功能必须进行研究。
In the hyperpigmented Silky (SK) chicken, melanoblasts are neural crest cells that emigrate from the neural tube, migrate dorsolaterally, close to the ectoderm and medioventrally, reaching visceral regions of the embryo, as well as populating the dermis. In this work, we analyzed the morphology and distribution of melanocytic lineage cells in white SK embryos at later stages of development (6 to 19 days of incubation) focusing in the dermis of dorsal skin to characterize this ectopically located population. Melanoblasts and immature melanocytes are seen at all analyzed stages, some of them clearly proliferative, suggesting a possibility of continued renewal of the population. Mature, fully differentiated melanocytes are elongated cells with many long cytoplasmic processes, forming a meshwork in superficial dermis, below a layer of collagen and elastic fibers that seems to prevent melanocytic lineage cells from reaching the epidermis at these later stages. SK chicken is the only Gallus gallus breed to display this arrangement of dermal melanocytes. The distribution of melanocytes below the collagen layer, observed in regions covered by feathers, is clearly not related with structural coloration as in areas of bare skin. Other functions for this conserved trait in SK must be investigated.