Orbitofrontal cortex and social behavior: Integrating self-monitoring and emotion-cognition interactions
Orbitofrontal cortex and social behavior: Integrating self-monitoring and emotion-cognition interactions
复制标题
DOI：
10.1162/jocn.2006.18.6.871
复制
发表时间：
2006-06-01
影响因子：
3.2
通讯作者：
Knight, Robert T.
中科院分区：
文献类型：
--
作者：
Beer, Jennifer S.;John, Oliver P.;Knight, Robert T.
眶额皮层在社会行为中的作用仍然是一个谜。关于眶额皮质的社会功能的各种理论都集中在这个区域在情绪处理或参与在线行为监测中的作用上（即，自我监督）。本研究试图整合这两个理论，通过检查是否提高眶额损伤患者的自我监控与指导人际行为所需的情绪的产生。眶额损伤患者、外侧前额叶损伤患者和健康对照者参与了一项人际关系任务。完成任务后，通过向参与者展示他们任务表现的录像带来增强他们的自我监控。与健康人、对照组和外侧前额叶损伤患者相比，眶额损伤与客观上不适当的社会行为有关。虽然眶额损伤的患者意识到亲密的社会规范，他们没有意识到他们的任务表现违反了这些规范。这些患者只有在观看了自己的录像表现后，自我监控增加后，才会出现通常与不适当的社会行为相关的尴尬。这些发现表明，眶额皮层的损伤会损害自我洞察力，从而可能妨碍有用的情感信息的产生。研究结果强调了眶额皮质在自我监控和情绪处理相互作用中的作用，并为眶额损伤后社交缺陷患者的神经康复提供了途径。
The role of the orbitofrontal cortex in social behavior remains a puzzle. Various theories of the social functions of the orbitofrontal cortex focus on the role of this area in either emotional processing or its involvement in online monitoring of behavior (i.e., self-monitoring). The present research attempts to integrate these two theories by examining whether improving the self-monitoring of patients with orbitofrontal damage is associated with the generation of emotions needed to guide interpersonal behavior. Patients with orbitofrontal damage, patients with lateral prefrontal damage, and healthy controls took part in an interpersonal task. After completing the task, participants' self-monitoring was increased by showing them a videotape of their task performance. In comparison to healthy, controls and patients with lateral prefrontal damage, orbitofrontal damage was associated with objectively inappropriate social behavior. Although patients with orbitofrontal damage were aware of social norms of intimacy, they were unaware that their task performance violated these norms. The embarrassment typically associated with inappropriate social behavior was elicited in these patients only after their self-monitoring increased from viewing their videotaped performance. These findings suggest that damage to the orbitofrontal cortex impairs self-insight that may preclude the generation of helpful emotional information. The results highlight the role of the orbitofrontal cortex in the interplay of self-monitoring and emotional processing and suggest avenues for neurorehabilitation of patients with social deficits subsequent to orbitofrontal damage.