Soy isoflavone supplementation and bone mineral density in menopausal women: a 2-y multicenter clinical trial
Soy isoflavone supplementation and bone mineral density in menopausal women: a 2-y multicenter clinical trial
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DOI：
10.3945/ajcn.2009.28001
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发表时间：
2009-11-01
影响因子：
7.1
通讯作者：
Smith, E. O'Brian
中科院分区：
文献类型：
--
作者：
Wong, William W.;Lewis, Richard D.;Smith, E. O'Brian
背景：异黄酮是天然存在的植物雌激素，在大豆中含量丰富。虽然声称可以防止骨质流失，但大豆蛋白补充剂在预防绝经后妇女骨质疏松症方面的功效仍然存在争议。目的：我们的目的是测试大豆蛋白补充剂对骨骼健康的影响。设计：一项多中心、随机、双盲、安慰剂对照24-进行mo试验以评估每日补充80或120 mg大豆胚轴糖苷配基黄酮加钙和维生素D对403名绝经后妇女。研究对象每年进行一次测试，并评估全身和局部骨矿物质密度（BMD）、骨矿物质含量（BMC）和T评分的变化。骨代谢的血清生化标志物的变化也assessed.Results：研究地点后，大豆摄入量，和预处理值进行了控制，受试者接受每日补充120毫克大豆黄酮有一个统计学显着较小的减少全身骨密度比安慰剂组在1年（P < 0.03）和2年（P < 0.05）的治疗。在这组妇女中，在治疗1年时观察到全身BMD T评分的较小下降（P，0.03），但在治疗2年时没有观察到。当与安慰剂相比，大豆异黄酮补充没有影响的变化，区域BMD，BMC，T评分，或骨代谢的生化标志物。结论：每天补充120毫克大豆胚轴异黄酮减少全身骨丢失，但不减缓骨丢失在常见的骨折部位在健康的绝经后妇女。该试验在临床试验中注册。gov as NCT 00665860.美国临床营养杂志2009; 90：1433-9。
Background: Isoflavones are naturally occurring plant estrogens that are abundant in soy. Although purported to protect against bone loss, the efficacy of soy isoflavone supplementation in the prevention of osteoporosis in postmenopausal women remains controversial.Objective: Our aim was to test the effect of soy isoflavone supplementation on bone health.Design: A multicenter, randomized, double-blind, placebo-controlled 24-mo trial was conducted to assess the effects of daily supplementation with 80 or 120 mg of soy hypocotyl aglycone isoflavones plus calcium and vitamin D on bone changes in 403 postmenopausal women. Study subjects were tested annually and changes in whole-body and regional bone mineral density (BMD), bone mineral content (BMC), and T scores were assessed. Changes in serum biochemical markers of bone metabolism were also assessed.Results: After study site, soy intake, and pretreatment values were controlled for, subjects receiving a daily supplement with 120 mg soy isoflavones had a statistically significant smaller reduction in whole-body BMD than did the placebo group both at 1 y (P < 0.03) and at 2 y (P < 0.05) of treatment. Smaller decreases in whole-body BMD T score were observed among this group of women at 1 y ( P, 0.03) but not at 2 y of treatment. When compared with the placebo, soy isoflavone supplementation had no effect on changes in regional BMD, BMC, T scores, or biochemical markers of bone metabolism.Conclusion: Daily supplementation with 120 mg soy hypocotyl isoflavones reduces whole-body bone loss but does not slow bone loss at common fracture sites in healthy postmenopausal women. This trial was registered at clinicaltrials. gov as NCT00665860. Am J Clin Nutr 2009; 90: 1433-9.