MULTIPLE MITOCHONDRIAL-DNA DELETIONS ASSOCIATED WITH AGE IN SKELETAL-MUSCLE OF RHESUS-MONKEYS
MULTIPLE MITOCHONDRIAL-DNA DELETIONS ASSOCIATED WITH AGE IN SKELETAL-MUSCLE OF RHESUS-MONKEYS
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DOI：
10.1093/geronj/48.6.b201
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发表时间：
1993-11-01
期刊：
影响因子：
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通讯作者：
AIKEN, JM
中科院分区：
文献类型：
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作者：
LEE, CM;CHUNG, SS;AIKEN, JM
我们检查了 16 只恒河猴（年龄范围 6-27 岁）的骨骼肌是否存在与年龄相关的线粒体 DNA (mtDNA) 缺失。所有 13 岁以上的动物都含有潜在的 mtDNA 缺失，而在年幼的动物中，缺失的存在大大减少或不存在。具体的删除模式因人而异。非人类灵长类动物的骨骼肌中随着年龄的增长，大量 mtDNA 缺失不断积累，这表明恒河猴可能为研究 mtDNA 缺失提供了一个极好的动物模型。此外，多重 mtDNA 缺失的存在支持了它们可能导致老年肌肉缺陷的可能性，这种缺陷几乎普遍存在，但人们却知之甚少。
We have examined skeletal muscle for the presence of age-associated mitochondrial DNA (mtDNA) deletions from 16 rhesus monkeys (age range 6-27 years). All animals over 13 years of age contained potential mtDNA deletions, whereas the presence of deletions was greatly reduced or absent in younger animals. The specific deletion patterns varied from individual to individual. Numerous mtDNA deletions accumulate with age in skeletal muscle from a nonhuman primate, indicating that the rhesus monkey may provide an excellent animal model to study mtDNA deletions. Further, the existence of multiple mtDNA deletions supports the possibility that they may contribute to geriatric muscular deficits, which are nearly universal in occurrence yet poorly understood.