Translational bioinformatics in the cloud: an affordable alternative.
Translational bioinformatics in the cloud: an affordable alternative.
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DOI:
10.1186/gm172
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发表时间:
2010-08-06
期刊:
影响因子:
12.3
通讯作者:
Butte AJ
中科院分区:
文献类型:
--
作者:
Dudley JT;Pouliot Y;Chen R;Morgan AA;Butte AJ
With the continued exponential expansion of publicly available genomic data and access to low-cost, high-throughput molecular technologies for profiling patient populations, computational technologies and informatics are becoming vital considerations in genomic medicine. Although cloud computing technology is being heralded as a key enabling technology for the future of genomic research, available case studies are limited to applications in the domain of high-throughput sequence data analysis. The goal of this study was to evaluate the computational and economic characteristics of cloud computing in performing a large-scale data integration and analysis representative of research problems in genomic medicine. We find that the cloud-based analysis compares favorably in both performance and cost in comparison to a local computational cluster, suggesting that cloud computing technologies might be a viable resource for facilitating large-scale translational research in genomic medicine.
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影响因子:
12.3
作者:
Gentleman RC;Carey VJ;Bates DM;Bolstad B;Dettling M;Dudoit S;Ellis B;Gautier L;Ge Y;Gentry J;Hornik K;Hothorn T;Huber W;Iacus S;Irizarry R;Leisch F;Li C;Maechler M;Rossini AJ;Sawitzki G;Smith C;Smyth G;Tierney L;Yang JY;Zhang J
通讯作者:
Zhang J
DOI:
10.1197/jamia.m2824
发表时间:
2008-11-01
影响因子:
6.4
作者:
Butte, Atul J.
通讯作者:
Butte, Atul J.
影响因子:
14.9
作者:
Barrett, Tanya;Troup, Dennis B.;Wilhite, Stephen E.;Ledoux, Pierre;Rudnev, Dmitry;Evangelista, Carlos;Kim, Irene F.;Soboleva, Alexandra;Tomashevsky, Maxim;Edgar, Ron
通讯作者:
Edgar, Ron
影响因子:
9.9
作者:
Dudley JT;Tibshirani R;Deshpande T;Butte AJ
通讯作者:
Butte AJ
DOI:
10.1093/bioinformatics/btp236
发表时间:
2009-06-01
期刊:
Bioinformatics (Oxford, England)
影响因子:
--
作者:
Schatz MC
通讯作者:
Schatz MC