Nanoassemblies constructed from bimodal mesoporous silica nanoparticles and surface-coated multilayer pH-responsive polymer for controlled delivery of ibuprofen
Nanoassemblies constructed from bimodal mesoporous silica nanoparticles and surface-coated multilayer pH-responsive polymer for controlled delivery of ibuprofen
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由双峰介孔二氧化硅纳米颗粒和表面涂覆的多层 pH 响应聚合物构建的纳米组件，用于控制布洛芬的输送
DOI：
10.1177/0885328216653287
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发表时间：
2016
影响因子：
2.9
通讯作者：
Jin Xiaoqi
中科院分区：
文献类型：
--
作者：
Guo Yueyue;Sun Jihong;Bai Shiyang;Jin Xiaoqi
采用一种简便的方法制备了pH敏感的聚（D-A）接枝胺功能化的双峰介孔氧化硅（D-A/BH 2 O），并将其用作药物载体。它们表现出优良的上级性能，例如在水介质中良好的分散性、高载药效率、改善的稳定性和高药物释放速率。同时，采用XRD、N2吸附-脱附、SEM、TEM、FT-IR、元素分析和TG等技术，系统地研究了其结构特征及其对布洛芬（IBU）控释作用的影响。结果表明，通过控制胺化双酚A介孔表面D-A的接枝量，得到的纳米复合材料呈现出对药物释放的灵活控制。发现在pH 7.4下IBU从D-A/BdR的累积释放百分比比在pH 2.0下高得多。由于酸性介质中的氢键作用和碱性介质中带负电荷的羧基之间的静电排斥作用，在酸性介质中释放速率非常慢，但在中性介质中释放速率变得更快。
The pH-sensitive poly(D-A) grafted amine-functionalized bimodal mesoporous silica (D-A/BMMs) was prepared by a facile method used as a drug delivery vehicle. They exhibited superior properties such as good dispersion in aqueous medium, high drug loading efficiency, improved stability and high drug release rates. Meanwhile, its structural features and performances in a controlled delivery of ibuprofen (IBU) were systematically investigated by using XRD, N2 adsorption and desorption, SEM, TEM, FT-IR, elemental analysis and TG techniques. The results demonstrated that the obtained nanocomposite presented a flexible control over drug release by controlling the grafting amount of D-A onto the mesopores surface of aminated BMMs. The cumulative percent release of IBU from D-A/BMMs was found to be much higher at pH 7.4 than at pH 2.0. The release rate was very slow in an acidic medium but became faster in a neutral medium, owing to hydrogen bonding in an acidic medium and electrostatic repulsion between negatively charged carboxyl groups in an alkaline medium.