The Conformation of Polymers at Interfaces
The Conformation of Polymers at Interfaces
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聚合物界面的构象
DOI：
10.1021/bk-1997-0680.ch003
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发表时间：
1997
影响因子：
3
通讯作者：
D. Lasič
中科院分区：
文献类型：
--
作者：
D. Lasič
用柔性聚合物涂覆各种表面和胶体颗粒大大减少了吸附，并增加了表面的生物相容性和胶体颗粒的稳定性。此外，这种颗粒的免疫原性和抗原性显著降低。这些发现在制备无污染和生物相容性表面方面非常重要。在胶体溶液的情况下，聚乙二醇化的蛋白质和脂质体由于改善的生物稳定性而可作为新的医学制剂商业化。本文综述了这一理论模型以及利用渗透应力技术和表面力仪进行的一些实验。实验表明，这种简化的理论适合实验数据以及更复杂的处理，表明这种系统的一般性质可以通过一个相当简单的理论方法来建模。
Coating of various surfaces and colloidal particles with flexible polymers greatly reduces adsorption and increases biological compatibility of surfaces and stability of colloidal particles. In addition, the immunogenicity and antigenicity of such particles decreases drastically. These findings are extremely important in the preparation of non-fouling and biocompatible surfaces. In the case of colloidal solutions, PEGylated proteins and liposomes are commercially available as novel medical formulations due to improved biological stability.The behavior of flexible polymers attached to the surface can be explained theoretically by the scaling theory. In this article this theoretical model as well as some experiments using osmotic stress technique and surface force apparatus are reviewed. Experiments show that this simplified theory fits experimental data as well as more complex treatments, indicating that general properties of such systems can be modeled by a rather simple theoretical approach.