Stanniocalcin 2 expression is associated with a favourable outcome in male breast cancer.
Stanniocalcin 2 expression is associated with a favourable outcome in male breast cancer.
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DOI：
10.1002/cjp2.106
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发表时间：
2018-10
期刊：
影响因子：
--
通讯作者：
Speirs V
中科院分区：
文献类型：
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作者：
Coulson-Gilmer C;Humphries MP;Sundara Rajan S;Droop A;Jackson S;Condon A;Cserni G;Jordan LB;Jones LJ;Kanthan R;Di Benedetto A;Mottolese M;Provenzano E;Kulka J;Shaaban AM;Hanby AM;Speirs V
乳腺癌可以发生在任何性别；然而，在男性中很少见，占确诊病例的不到1%。在先前的男性乳腺癌（MBC）和女性乳腺癌（FBC）的转录组学筛查中，我们观察到Stanniocalcin 2 （STC2）在前者中过表达。本研究的目的是确认STC2在MBC中的表达，并探讨其是否对患者预后有影响。在早期的转录组筛选之后，通过RT - qPCR在匹配的MBC和FBC样本以及来自不同性别的肿瘤相关成纤维细胞中证实了STC2基因的表达。随后，用免疫组织化学方法检测了477例MBC患者组织微阵列中STC2蛋白的表达。使用Kaplan-Meier法计算累积生存概率，使用Cox风险模型进行多变量生存分析。性别特异性STC2基因表达在MBC中显示出5.6倍的STC2转录上调，这也得到Oncomine™数据的支持。STC2蛋白表达是无病生存的一个阳性预后因素（DFS; Log‐rank；总p = 0.035, HR = 0.49；肿瘤细胞p = 0.017, HR = 0.44；基质p = 0.030, HR = 0.48），但对总生存无显著影响（Log‐rank；总p = 0.23, HR = 0.71；肿瘤细胞p = 0.069, HR = 0.59；基质p = 0.650, HR = 0.87）。重要的是，多因素分析调整了患者的诊断年龄、淋巴结分期、肿瘤大小、ER和PR状态，结果显示STC2的总表达以及肿瘤细胞中的表达是DFS的独立预后因素（Cox回归；p = 0.018, HR = 0.983; p = 0.015, HR = 0.984）。总之，STC2在MBC中表达丰富，是DFS的独立预后因素。
Breast cancer can occur in either gender; however, it is rare in men, accounting for <1% of diagnosed cases. In a previous transcriptomic screen of male breast cancer (MBC) and female breast cancer (FBC) occurrences, we observed that Stanniocalcin 2 (STC2) was overexpressed in the former. The aim of this study was to confirm the expression of STC2 in MBC and to investigate whether this had an impact on patient prognosis. Following an earlier transcriptomic screen, STC2 gene expression was confirmed by RT‐qPCR in matched MBC and FBC samples as well as in tumour‐associated fibroblasts derived from each gender. Subsequently, STC2 protein expression was examined immunohistochemically in tissue microarrays containing 477 MBC cases. Cumulative survival probabilities were calculated using the Kaplan–Meier method and multivariate survival analysis was performed using the Cox hazard model. Gender‐specific STC2 gene expression showed a 5.6‐fold upregulation of STC2 transcripts in MBC, also supported by data deposited in Oncomine™. STC2 protein expression was a positive prognostic factor for disease‐free survival (DFS; Log‐rank; total p = 0.035, HR = 0.49; tumour cells p = 0.017, HR = 0.44; stroma p = 0.030, HR = 0.48) but had no significant impact on overall survival (Log‐rank; total p = 0.23, HR = 0.71; tumour cells p = 0.069, HR = 0.59; stroma p = 0.650, HR = 0.87). Importantly, multivariate analysis adjusted for patient age at diagnosis, node staging, tumour size, ER, and PR status revealed that total STC2 expression as well as expression in tumour cells was an independent prognostic factor for DFS (Cox regression; p = 0.018, HR = 0.983; p = 0.015, HR = 0.984, respectively). In conclusion, STC2 expression is abundant in MBC where it is an independent prognostic factor for DFS.
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