C-H Silylation of 2‐Arylpyridine Derivatives by Using Iridium Catalyst and Phosphine‐Borane Ligand
C-H Silylation of 2‐Arylpyridine Derivatives by Using Iridium Catalyst and Phosphine‐Borane Ligand
复制标题
铱催化剂和膦硼烷配体对 2-芳基吡啶衍生物进行 C-H 硅烷化反应
DOI：
10.1002/adsc.202101476
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发表时间：
2022
影响因子：
5.4
通讯作者：
Masanari Kimura
中科院分区：
文献类型：
--
作者：
Keita Anoyama;Gen Onodera;Tsutomu Fukuda;Masanari Kimura
研究了铱催化的2-芳基吡啶衍生物与氢硅烷的邻位-C-H硅烷基化反应。各种2-芳基吡啶可用于该反应，以81-99%的产率得到单甲硅烷基化和二甲硅烷基化的产物。在该反应中，磷和硼之间的键长对反应的进行起重要作用。我们认为2-芳基吡啶中的氮与配体中的刘易斯酸性硼配位，从而导致铱的邻位− C-H键断裂。
Iridium‐catalyzedortho−C−H silylation of 2‐arylpyridine derivative with hydrosilane by using phosphine‐borane ligand has been developed. A variety of 2‐arylpyridines could be used for this reaction to give mono‐ and disilylated products in 81–99% yields. In this reaction, the length of linkage between phosphorus and boron plays an important role for the reaction to proceed. We consider that the nitrogen in 2‐arylpyridine coordinates to Lewis acidic boron in the ligand and thus the iridium is led to anortho−C−H bond to cleave it.