The NQO1 C609T polymorphism is associated with risk of secondary malignant neoplasms after treatment for childhood acute lymphoblastic leukemia: a matched-pair analysis from the ALL-BFM study group
The NQO1 C609T polymorphism is associated with risk of secondary malignant neoplasms after treatment for childhood acute lymphoblastic leukemia: a matched-pair analysis from the ALL-BFM study group
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DOI：
10.3324/haematol.10260
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发表时间：
2007-11
期刊：
影响因子：
10.1
通讯作者：
M. Stanulla;C. Dynybil;D. Bartels;M. Dördelmann;L. Löning;A. Claviez;M. Schrappe
中科院分区：
文献类型：
--
作者：
M. Stanulla;C. Dynybil;D. Bartels;M. Dördelmann;L. Löning;A. Claviez;M. Schrappe
在一项配对研究中，我们分析了表型相关的NQO1多态性（C609T）与儿童急性淋巴细胞白血病治疗后继发恶性肿瘤（SMN）风险的相关性。携带变异低活性NQO1等位基因的患者发生SMN的风险显著增加。观察到的效果仅限于实体瘤。
In a matched-pair study, we analyzed the association of a phenotypically relevant NQO1 polymorphism (C609T) with risk of secondary malignant neoplasms (SMN) after treatment for childhood acute lymphoblastic leukemia. Patients carrying a variant low-activity NQO1 allele had a significantly increased risk of developing a SMN. The observed effect was restricted to solid tumors.