Enantio- and diastereocontrolled total synthesis of (+)-boronolide
Enantio- and diastereocontrolled total synthesis of (+)-boronolide
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DOI：
10.1021/jo0603781
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发表时间：
2006-05-12
影响因子：
3.6
通讯作者：
Naidu, SV
中科院分区：
文献类型：
--
作者：
Kumar, P;Naidu, SV
报道了一种由戊醛合成(+)-硼内酯的高效立体选择性全合成方法。关键步骤包括夏普莱斯不对称羟基化、螯合控制的乙烯基格氏反应、随后的夏普莱斯不对称环氧化、水解动力学拆分和闭环歧化反应。
An efficient stereoselective total synthesis of (+)-boronolide from valeraldehyde is described. The key steps include a Sharpless asymmetric hydroxylation, a chelation-controlled vinyl Grignard reaction followed by a Sharpless asymmetric epoxidation, hydrolytic kinetic resolution, and a ring-closing metathesis.