An acute intraocular pressure challenge to assess retinal ganglion cell injury and recovery in the mouse
An acute intraocular pressure challenge to assess retinal ganglion cell injury and recovery in the mouse
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DOI：
10.1016/j.exer.2015.03.006
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发表时间：
2015-12-01
影响因子：
3.4
通讯作者：
Chrysostomou, Vicki
中科院分区：
文献类型：
--
作者：
Crowston, Jonathan G.;Kong, Yu Xiang G.;Chrysostomou, Vicki
我们描述了一种小鼠眼急性眼内压（IOP）升高模型，该模型诱导与氧化应激、胶质细胞活化和视网膜神经节细胞（RGC）数量最小损失相关的视网膜内功能可逆性丧失。年轻的健康小鼠眼睛在7天内恢复内部视网膜功能，但在老年小鼠中观察到更持久的功能丧失。饮食和运动的操纵进一步修改RGC恢复，证明了这种损伤模型用于研究生活方式和治疗干预的实用性。我们相信，对IOP挑战后RGC恢复的特征和决定因素的系统研究将揭示青光眼早期阶段RGC脆弱性的过程。(C)2015爱思唯尔有限公司版权所有。
We describe a model of acute intraocular pressure (IOP) elevation in the mouse eye that induces reversible loss of inner retinal function associated with oxidative stress, glial cell activation and minimal loss of retinal ganglion cell (RGC) number. Young healthy mouse eyes recover inner retinal function within 7-days but more persistent functional loss is seen in older mice. Manipulation of diet and exercise further modify RGC recovery demonstrating the utility of this injury model for investigating lifestyle and therapeutic interventions. We believe that systematic investigation into the characteristics and determinants of RGC recovery following an IOP challenge will shed light on processes that govern RGC vulnerability in the early stages of glaucoma. (C) 2015 Elsevier Ltd. All rights reserved.