Relationship between salivary immunoglobulin a, lactoferrin and lysozyme flow rates and lifestyle factors in Japanese children: a cross-sectional study
Relationship between salivary immunoglobulin a, lactoferrin and lysozyme flow rates and lifestyle factors in Japanese children: a cross-sectional study
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DOI：
10.1080/00016357.2016.1223340
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发表时间：
2016-01-01
影响因子：
2
通讯作者：
Tsukinoki, Keiichi
中科院分区：
文献类型：
--
作者：
Ide, Momo;Saruta, Juri;Tsukinoki, Keiichi
目的：唾液中的抗菌物质有助于维护口腔健康和身体的整体健康。因此，免疫球蛋白A（伊加），乳铁蛋白和溶菌酶在儿童唾液中的流速之间的关联，和他们的身体属性和生活方式的儿童因素的关系，examined.Materials和方法：唾液收集90名儿童谁访问了神奈川齿科大学医院儿童牙科，并完成问卷调查的监护人。采用酶联免疫吸附试验（ELISA）检测唾液中伊加、乳铁蛋白和溶菌酶的含量。发现乳铁蛋白和溶菌酶流速之间存在相关性。当根据最高和最低四分位数将唾液中的抗菌物质流速分为两组，每组22名儿童时，伊加流速低或高的儿童也分别具有高或低的乳铁蛋白流速。观察到相同的模式乳铁蛋白和溶菌酶floweres.Conclusions：有一个很高的概率，在儿童的唾液中的伊加流速反映和对应的免疫功能的发育状态，作为儿童年龄和身高和体重的增加。儿童乳铁蛋白和溶菌酶的流速具有相关性。此外，关于生活方式因素，睡眠时间和乳铁蛋白流速也相关。
Objective: The antimicrobial substances in saliva contribute to the maintenance of both oral health and overall health of the body. Therefore, the associations among immunoglobulin A (IgA), lactoferrin and lysozyme flow rates in the saliva of children, and their relationships with the physical attributes and lifestyle factors of children, were examined.Materials and methods: Saliva was collected from 90 children who visited the Kanagawa Dental University Hospital Pediatric Dentistry, and questionnaires were completed by guardians. IgA, lactoferrin and lysozyme concentrations were measured in the saliva samples using enzyme-linked immunosorbent assays (ELISAs).Results: The IgA flow rate in saliva increased as age, height and weight increased. A correlation was found between lactoferrin and lysozyme flow rates. When the antimicrobial substance flow rates in the saliva were divided into two groups of 22 children each based on the highest and lowest quartiles, children with either a low or high IgA flow rate also had a high or low lactoferrin flow rate, respectively. The same pattern was observed for lactoferrin and lysozyme flow rates.Conclusions: There is a high probability that the IgA flow rate in the saliva of children reflects and corresponds to the developmental status of immune function as the child ages and increases in height and weight. The flow rates of lactoferrin and lysozyme were correlated in children. In addition, regarding lifestyle factors, the duration of sleep and lactoferrin flow rate were also related.