Anxiolytic and anxiogenic effects of kindling - role of baseline anxiety and anatomical location of the kindling electrode in response to kindling of the right and left basolateral amygdala
Anxiolytic and anxiogenic effects of kindling - role of baseline anxiety and anatomical location of the kindling electrode in response to kindling of the right and left basolateral amygdala
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DOI：
10.1016/j.bbr.2004.10.004
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发表时间：
2005-04-15
影响因子：
2.7
通讯作者：
Burton, P
中科院分区：
文献类型：
--
作者：
Adamec, R;Shallow, T;Burton, P
研究了左右基底外侧杏仁核（BLA）点燃对十字迷宫焦虑的影响。使用经过验证的重新测试范例，可以在 Plus 迷宫中重新测试大鼠，而不会增加重新测试时的焦虑。这使得可以确定点燃前的正迷宫焦虑的基线水平。高基线焦虑大鼠的右 BLA 点燃在点燃后一周即可抗焦虑。右 BLA 点燃低基线焦虑大鼠是致焦虑的。此外，左 BLA 点燃要么引起焦虑，要么对正迷宫焦虑没有影响，具体取决于基线焦虑。左 BLA 的作用与之前显示左 BLA 点燃的抗焦虑作用的研究不同。这种差异的部分原因可能是基线焦虑的预激。这些发现需要修改之前的结论，即在正号迷宫中，左半球（左 BLA）引火物具有抗焦虑作用，而右 BLA 引火物具有致焦虑作用。相反，大脑半球的差异可能是由于基线焦虑水平和点燃之间的相互作用造成的。如果属实，啮齿类动物的焦虑性格可能会与杏仁核点火相互作用，从而以不同的方式改变杏仁核的功能。还描述了点燃和基线焦虑对其他行为（例如风险评估和抵抗捕获）的影响。根据过去的研究，目前的数据表明，病前焦虑状态和引火电极的位置都有助于引火对行为的影响 (c) 2004 Elsevier B.V. 保留所有权利。
Effects of kindling of right and left basolateral amygdala (BLA) on plus maze anxiety was Studied. Using a validated retest paradigm, it was possible to retest rats in the Plus maze without increasing anxiety on retest. This permitted determining prekindling g baseline levels of plus maze anxiety. Right BLA kindling of high baseline anxiety rats was anxiolytic one week after kindling. Right BLA kindling of low baseline anxiety rats was anxiogenic. In addition, left BLA kindling was either anxiogenic or without effect on plus maze anxiety, depending on baseline anxiety. Effects in left BLA differ from previous work showing anxiolytic effects of left BLA kindling. The discrepancy could be explained in part by prekindling baseline anxiety. These findings require modification of the previous conclusion that left hemisphere (left BLA) kindling is anxiolytic and right BLA kindling is anxiogenic in the Plus maze. Rather the hemisphere difference may be due to an interaction between baseline anxiety level and kindling. If true, anxious disposition in rodents may interact with amygdala kindling to change amygdala function differently. Kindling and baseline anxiety effects oil other behaviors (such as risk assessment and resistance to capture) are also described. Present data in the light of past Studies suggest both premorbid anxiety state and location of the kindling electrode contribute to the effects of kindling on behavior (c) 2004 Elsevier B.V. All rights reserved.