Development of the neural retina and its vasculature in the marmoset Callithrix jacchus
Development of the neural retina and its vasculature in the marmoset Callithrix jacchus
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DOI：
10.1002/cne.20996
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发表时间：
2006-07-10
影响因子：
2.5
通讯作者：
Springer, Alan
中科院分区：
文献类型：
--
作者：
Hendrickson, Anita;Troilo, David;Springer, Alan
新世界绒猴Callithrix jacchus视网膜发育的形态序列与以往在猕猴和人类中的报道相似。早期的中央凹在胎儿日（Fd）100时作为视网膜的唯一部分存在，其包含五个不同的层，包括单层视锥光感受器。在Fd 135处，在被血管（BV）和星形胶质细胞环包围的中心凹无血管区的中心开始形成中心凹。出生时（Fd 144），中央凹在小凹中心上方有单层锥体，其中视网膜内层变薄但仍然分离。出生后，黄斑中心凹迅速成熟，4个月时黄斑中心凹锥体和凹窝形态与成人相似。新生绒猴视网膜边缘有5层不同的神经纤维层和BV神经丛。在视盘附近，BV在出生时发芽到视网膜外层，并且视网膜外层的血管化在2至3个月内完成。视网膜长度急剧增加，直到Fd 135，但在出生前后经历了一个静止期，在此期间开始形成小窝。然后长度再次增加到4个月，然后缓慢增加到成年期。出生后的增长伴随着周边视网膜的显着变薄。睫状体平坦部在出生后出现，其长度至少增加到2岁。绒猴和猕猴的主要区别是出生时绒猴的中央凹相对不成熟，出生后发育迅速。这使得绒猴成为视网膜和眼睛发育的新生儿实验操作的良好候选者。
The morphological sequence of retinal development in the New World marmoset monkey Callithrix jacchus is similar to previous reports in Macaca and humans. The incipient fovea is present at fetal day (Fd) 100 as the only part of the retina that contains five distinct layers, including a single layer of cone photoreceptors. A foveal pit begins to form at Fd 135 in the center of the foveal avascular zone which is surrounded by a ring of blood vessels (BV) and astrocytes. At birth (Fd 144) the fovea has a single layer of cones over the pit center where the inner retinal layers are thinned but still separated. After birth the fovea rapidly matures so that foveal cone and pit morphology are similar to adult by 4 months. Five distinct layers and the BV plexus in the nerve fiber layer are present to the retinal edge in neonatal marmosets. Near the optic disc BV are sprouting into outer retinal layers at birth and vascularization of the outer retina is completed by 2 to 3 months. Retinal length increases sharply up to Fd 135, but undergoes a quiescent period around birth during which pit formation begins. Length then increases again up to 4mo, followed by a slow increase into adulthood. The postnatal increase is accompanied by a marked thinning of the peripheral retina. The pars plana appears after birth and its length increases at least until 2 years of age. The major difference between marmoset and Macaca is the relative immaturity of the marmoset fovea at birth, and its rapid development after birth. This makes the marmoset a good candidate for neonatal experimental manipulation of retinal and eye development.