Riluzole and methylprednisolone combined treatment improves functional recovery in traumatic spinal cord injury.
Riluzole and methylprednisolone combined treatment improves functional recovery in traumatic spinal cord injury.
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DOI：
10.1089/neu.2000.17.773
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发表时间：
2000-09
影响因子：
4.2
通讯作者：
Xiaojun Mu;Robert D. Azbill;Joe E. Springer
中科院分区：
文献类型：
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作者：
Xiaojun Mu;Robert D. Azbill;Joe E. Springer
研究了利鲁唑（一种谷氨酸释放抑制剂）单独或与甲基泼尼松龙（MP）联合治疗急性脊髓损伤（SCI）的潜在用途。使用 NYU 撞击器对大鼠造成脊髓挫伤，并在损伤后 2 小时和 4 小时用赋形剂、利鲁唑 (8 mg/kg)、MP (30 mg/kg) 或利鲁唑 + MP 进行治疗。动物继续接受利鲁唑治疗（8 mg/kg）1周。然后每周使用 BBB 开放场运动评分对动物进行功能恢复测试。测试结束时（损伤后 6 周），检查每根脊髓损伤部位剩余组织的数量，并使用髓鞘形成指数来量化腹内侧白质中剩余的轴突。在这项研究中，根据 BBB 开放场运动量表的评估，发现只有联合治疗才能显着改善行为恢复。此外，联合治疗促进了病变中心的组织保留，但对髓鞘形成指数没有明显影响。这项研究的结果清楚地证明了联合治疗创伤性 SCI 的潜在有益效果。
The potential use of riluzole (a glutamate release inhibitor) alone or in combination with methyl-prednisolone (MP) in treating acute spinal cored injury (SCI) was examined. Rats received a contusion injury to the spinal cord using the NYU impactor and were treated with vehicle, riluzole (8 mg/kg), MP(30 mg/kg), or riluzole + MP at 2 and 4 h following injury. Animals continued to receive riluzole treatment (8 mg/kg) for a period of 1 week. The animals were then tested weekly for functional recovery using the BBB open field locomotor score. At the end of testing (6 weeks after injury), each spinal cord was examined for the amount of remaining tissue at the injury site and a myelination index was used to quantify remaining axons in the ventromedial white matter. In this study, only the combination treatment was found to significantly improve behavioral recovery as assessed using the BBB open field locomotor scale. In addition, the combination treatment promoted tissue sparing at the lesion epicenter, but had no clear effect on the index of myelination. The results of this study clearly demonstrate the potential beneficial effects of a combination approach in the treatment of traumatic SCI.