IMMUNOGENICITY OF A STREPTOCOCCUS-PNEUMONIAE TYPE-4 POLYSACCHARIDE PROTEIN CONJUGATE VACCINE IS DECREASED BY ADMIXTURE OF HIGH-DOSES OF FREE SACCHARIDE
IMMUNOGENICITY OF A STREPTOCOCCUS-PNEUMONIAE TYPE-4 POLYSACCHARIDE PROTEIN CONJUGATE VACCINE IS DECREASED BY ADMIXTURE OF HIGH-DOSES OF FREE SACCHARIDE
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DOI：
10.1016/0264-410x(92)90046-m
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发表时间：
1992-01-01
期刊：
影响因子：
5.5
通讯作者：
RIJKERS, GT
中科院分区：
文献类型：
--
作者：
PEETERS, CCAM;TENBERGENMEEKES, AMJ;RIJKERS, GT
在这项研究中，我们报告说，4 型肺炎链球菌多糖-蛋白质缀合物对天然荚膜多糖加强免疫的引发能力是剂量依赖性的。此外，混合实验表明，同时给予不同链长（M(r) 1.6-120 kDa）的高剂量游离糖（0.5-25-mu-g）会降低抗多糖抗体反应。通常存在于通过碳酰亚胺偶联过程制备的缀合物中的低剂量糖（高达10%）的存在并不影响成年和新生小鼠中的抗多糖抗体反应。
In this study we report that the priming capacity of a Streptococcus pneumoniae type 4 polysaccharide-protein conjugate to booster immunizations with the native capsular polysaccharide is dose dependent. Furthermore, it is shown by admixture experiments that simultaneous administration of high doses of free saccharide (0.5-25-mu-g) of different chain lengths (varying from M(r) 1.6-120 kDa) decreases the anti-polysaccharide antibody response. Presence of low doses of saccharide (up to 10%), which are usually present in conjugates prepared by the carbo&imide coupling procedure, did not influence the anti-polysaccharide antibody response in adult and neonatal mice.