NICOTINE AND CARBON-MONOXIDE CONTENT OF CIGARETTE-SMOKE AND THE RISK OF MYOCARDIAL-INFARCTION IN YOUNG MEN
NICOTINE AND CARBON-MONOXIDE CONTENT OF CIGARETTE-SMOKE AND THE RISK OF MYOCARDIAL-INFARCTION IN YOUNG MEN
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DOI：
10.1056/nejm198302243080801
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发表时间：
1983-01-01
影响因子：
158.5
通讯作者：
SHAPIRO, S
中科院分区：
文献类型：
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作者：
KAUFMAN, DW;HELMRICH, SP;SHAPIRO, S
为了评估香烟烟雾中的尼古丁和一氧化碳含量是否与年轻男性非致死性第一心肌梗死的风险有关，502例患者与835名30-54岁的医院对照进行了比较。心肌梗死的估计风险随着吸烟数量的增加而增加；当前吸烟者的相对危险度估计为2.8（95%可信区间为2.0-4.0）。风险并没有因香烟中尼古丁或一氧化碳的含量而变化，而且每根香烟中这两种物质的平均含量与对照组相似。吸烟尼古丁和一氧化碳含量较低的新型香烟的男性患心肌梗死的风险并不比那些吸烟尼古丁和一氧化碳含量较高的人低。
To evaluate whether the nicotine and CO content of cigarette smoke was related to the risk of nonfatal 1st myocardial infarction in young men, 502 cases were compared with 835 hospital controls, aged 30-54 yr. The estimated risk of myocardial infarction increased with the number of cigarettes smoked; the relative-risk estimate for current smokers was 2.8 (95% confidence interval, 2.0-4.0). The risk did not vary according to the amount of nicotine or CO in the cigarette, and the mean amounts of both substances per cigarette were similar for the cases and controls. Men who smoked the newer cigarettes with reduced amounts of nicotine and CO did not have a lower risk of myocardial infarction than those who smoked cigarettes containing larger amounts of these substances.