Renal expression of IGF I in hypersomatotropic states.
Renal expression of IGF I in hypersomatotropic states.
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IGF I 在生长过度状态下的肾脏表达。
DOI：
10.1152/ajprenal.1990.259.2.f251
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Hammerman,MR
中科院分区：
文献类型：
--
作者：
Miller,SB;Rotwein,P;Bortz,JD;Bechtel,PJ;Hansen,VA;Rogers,SA;Hammerman,MR
我们研究了胰岛素样生长因子I（IGF I）基因表达在肾脏中的两种模型的过度生长，大鼠植入GH 3垂体瘤，和大鼠给予外源性生长激素（GH）。GH 3荷瘤大鼠和给予GH的大鼠的体重增加速度均快于对照组动物，肾脏也大于对照组。荷瘤大鼠的循环IGF I水平升高。取移植瘤大鼠的肾小球进行切片。免疫组织化学IGF I增加髓质收集管从荷瘤和GH注射大鼠与对照动物的肾脏相比。与对照组相比，植入GH 3肿瘤的大鼠和注射GH的大鼠肾脏中IGF I mRNA的水平升高。我们的研究结果表明，增强肾IGF-I基因表达的过度生长。GH刺激肾脏IGF I合成可能是GH过量状态（如肢端肥大症）中肾功能和肾脏大小变化的原因。
We examined insulin-like growth factor I (IGF I) gene expression in kidney in two models of hypersomatotropism, rats implanted with GH3 pituitary tumors, and rats administered exogenous growth hormone (GH). Both GH3 tumor-bearing rats and rats administered GH gained weight more rapidly than control animals, and had kidneys that were larger than those of controls. Tumor-bearing rats had increased levels of circulating IGF I. Glomeruli from tumor-implanted rats were sclerotic. Immunostainable IGF I was increased in medullary collecting ducts from tumor-bearing and GH-injected rats compared with kidneys from control animals. Levels of IGF I mRNA in kidneys of rats implanted with GH3 tumors and GH-injected rats were elevated compared with levels in kidneys from controls. Our findings demonstrate enhanced renal IGF I gene expression in hypersomatotropism. Stimulation of renal IGF I synthesis by GH could be causative of changes in renal function and renal size that occur in states of GH excess such as acromegaly.