Heterocyclic amines for the construction of peptoid oligomers bearing multi-dentate ligands
Heterocyclic amines for the construction of peptoid oligomers bearing multi-dentate ligands
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DOI：
10.1016/j.tetlet.2007.11.047
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发表时间：
2008-01-07
影响因子：
1.8
通讯作者：
Kirshenbaum, Kent
中科院分区：
文献类型：
--
作者：
Maayan, Galia;Yoo, Barney;Kirshenbaum, Kent
类肽是 N-取代甘氨酸的寡聚物，可以使用卤乙酸和伯胺作为合成子轻松组装。在这里，我们报告了三种新杂环胺的合成和表征，2-(2,2':6',2''-三联吡啶-4'-基氧基)乙胺、2-(1,10-菲咯啉-5-基氧基)乙胺和8-羟基-2-喹啉甲胺，以及将它们掺入到一系列不同的类肽寡聚物序列中。由于杂环都已知可配位金属离子，因此拟肽产品旨在结合金属物质，具有在催化和材料科学中应用的潜力。 (C) 2007 Elsevier Ltd. 保留所有权利。
Peptoids are oligomers of N-substituted glycine that can be readily assembled using haloacetic acids and primary amines as synthons. Here, we report the synthesis and characterization of three new heterocyclic amines, 2-(2,2':6',2 ''-terpyridine-4'-yloxy)ethylamine, 2-(1,10-phenanthroline-5-yloxy)ethylamine and 8-hydroxy-2-quinolinemethylamine, and their incorporation into a series of different peptoid oligomer sequences. Since the heterocycles are all known to coordinate metal ions, the peptidomimetic products are designed to bind metal species with the potential for applications in catalysis and materials science. (C) 2007 Elsevier Ltd. All rights reserved.