Feruloylated Oligosaccharides from Maize Bran Modulated the Gut Microbiota in Rats
Feruloylated Oligosaccharides from Maize Bran Modulated the Gut Microbiota in Rats
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DOI：
10.1007/s11130-016-0547-4
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发表时间：
2016-05
影响因子：
4
通讯作者：
J. Ou;Junqing Huang;Yuan Song;Sheng-wen Yao;Xichun Peng;Mingfu Wang;S. Ou
中科院分区：
文献类型：
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作者：
J. Ou;Junqing Huang;Yuan Song;Sheng-wen Yao;Xichun Peng;Mingfu Wang;S. Ou
玉米皮是玉米加工的副产品；它富含阿魏酸和半纤维素。本研究通过16S rRNA测序研究了玉米麸皮阿魏氨酸化寡糖（FOs）对大鼠粪便微生物多样性和特征的影响。与对照和单独添加低聚木糖（XOS）相比，FOs显著增加了细菌的丰富度和多样性。与对照组和XOS组相比，口服300 mg/kg FOs使粪便OTU分别提高57.0%和24.8%，Chao值分别提高93.4%和37.6%。FOs还会影响与肥胖和糖尿病相关的细菌。口服FOs 300 mg/kg使大肠杆菌与大肠杆菌的比值从477.7:1降至55.1:1；大大增加了以前在大鼠身上发现的抗糖尿病细菌的读数，如放线菌、拟杆菌和乳杆菌；而减少易患糖尿病的细菌，如梭状芽胞杆菌和厚壁菌。
Corn bran is a byproduct produced from corn milling; it is rich in ferulic acid and hemicellulose. In this research, the effects of feruloylated oligosaccharides (FOs) from maize bran on the microbial diversity and profiles in rat feces were investigated through 16S rRNA sequencing. FOs significantly increased bacterial richness and diversity compared with the control and xylooligosaccharides (XOS) alone. In comparison with the control group and the group administrated with XOS, FOs orally administered at 300 mg/kg increased OTU in feces by 57.0 and 24.8 %, and Chao value by 93.4 and 37.6 %, respectively. FOs also influenced obesity- and diabetes-associated bacteria. Oral administration of FOs at 300 mg/kg decreased the ratio ofFirmicutestoBacteroidetesfrom 477.7:1 to 55.1:1; greatly increased the reads of bacteria that were previously found resistant against diabetes in rats, such asActinobacteria,Bacteroides, andLactobacillus; whereas decreased diabetes-prone bacteria, such asClostridiumandFirmicutes.