Iron Deficiency and Cardiovascular Disease: An Updated Review of the Evidence
Iron Deficiency and Cardiovascular Disease: An Updated Review of the Evidence
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DOI：
10.1007/s11883-013-0358-0
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发表时间：
2013-10-01
影响因子：
5.8
通讯作者：
Vaccaro, Olga
中科院分区：
文献类型：
--
作者：
Lapice, Emanuela;Masulli, Maria;Vaccaro, Olga
体铁状态与心血管疾病(CVD)的发生有关。这种联系的生物学机制已经被描述，然而，关于铁状态和心血管疾病风险的流行病学研究提供了相互矛盾的结果。缺乏一致性很可能是因为研究设计、用于评估铁状态的测量方法、结果的定义以及对混杂因素的调整方面的差异。为了帮助澄清现有证据，我们报告了对已发表的横断面、纵向和干预性研究的系统回顾，这些研究评估了铁状态的不同测量与心血管疾病风险之间的关系。从现有研究中最有可能出现的情况是，在参考范围内，铁的状态具有中性影响。铁缺乏和铁超载的极端情况与心血管疾病风险的适度增加有关，尽管所提出的机制不同。
Body iron status has been suggested to be related to the development of cardiovascular disease (CVD). Biologically plausible mechanisms for this association have been described, however epidemiological studies on iron status and CVD risk have provided conflicting results. The lack of consistency is likely explained by differences in the study design, the measures used for the assessment of iron status, the definition of outcomes, and adjustment for confounders. To help clarify the available evidence, we report a systematic review of published cross-sectional, longitudinal, and intervention studies evaluating the relationship between different measures of iron status and CVD risk. The most likely scenario that emerges from the available studies is that, in the reference range, iron status has a neutral effect. Extreme conditions of iron deficiency, as well as of iron overload, are associated with modestly increased CVD risk, although with different proposed mechanisms.