Mitotic drive in asymmetric epigenetic inheritance.
Mitotic drive in asymmetric epigenetic inheritance.
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DOI：
10.1042/bst20200267
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发表时间：
2022-04-29
影响因子：
3.9
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中科院分区：
文献类型：
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不对称细胞分裂（ACD）产生两个具有不同细胞命运的子细胞。这种分裂模式在发育过程中被广泛使用，并且在组织稳态和再生过程中被成体干细胞广泛使用，这可以通过诸如信号分子的外在线索和诸如表观遗传信息的内在因素来调节。虽然DNA复制过程确保姐妹染色单体的序列是相同的，但在ACD期间表观遗传信息如何重新分布在多细胞生物中仍然很不清楚。果蝇雄性生殖干细胞（GSC）的研究表明，姐妹染色单体纳入预先存在的和新合成的组蛋白差异和分离不对称ACD期间。为了理解这种现象的潜在分子机制，必须回答两个关键问题：第一，如何以及何时建立不对称组蛋白信息;第二，表观遗传学上不同的姐妹染色单体如何区分和分离。在这里，我们讨论了最近的进展，帮助我们了解这个有趣的和重要的细胞分裂模式。
Asymmetric cell division (ACD) produces two daughter cells with distinct cell fates. This division mode is widely used during development and by adult stem cells during tissue homeostasis and regeneration, which can be regulated by both extrinsic cues such as signaling molecules and intrinsic factors such as epigenetic information. While the DNA replication process ensures that the sequences of sister chromatids are identical, how epigenetic information is re-distributed during ACD has remained largely unclear in multicellular organisms. Studies of Drosophila male germline stem cells (GSCs) have revealed that sister chromatids incorporate pre-existing and newly synthesized histones differentially and segregate asymmetrically during ACD. To understand the underlying molecular mechanisms of this phenomenon, two key questions must be answered: first, how and when asymmetric histone information is established; and second, how epigenetically distinct sister chromatids are distinguished and segregated. Here, we discuss recent advances which help our understanding of this interesting and important cell division mode.