CD14dim/CD13bright monocytes in hemophagocytic lymphohistiocytosis
CD14dim/CD13bright monocytes in hemophagocytic lymphohistiocytosis
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DOI：
10.1002/1521-4141(200106)31:6
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发表时间：
2001-06-01
影响因子：
5.4
通讯作者：
Urbanek, R
中科院分区：
文献类型：
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作者：
Emminger, W;Zlabinger, GJ;Urbanek, R
噬血细胞性淋巴组织细胞增生症（HLH）是一种由促炎细胞因子介导的极其罕见的高致死性慢性炎症性疾病。在患有HLH的男孩的外周血中，检测到CDI 4（暗淡）/CD 16（明亮）炎性单核细胞的慢性扩增。与CD 14（亮）单核细胞相比，其免疫表型与更成熟的单核细胞分化为巨噬细胞相关：它们显示出较低的CD 11b、CD 64和CD 35表达。这种CD 14（dim）/CD 16（bright）单核细胞产生炎性细胞因子IL-1 β、IL-6和TNF-α。它们很好地符合HLH作为淋巴细胞和单核细胞/巨噬细胞系统的炎症状态的病理生理学概念。在本例患者中，这些循环炎性单核细胞的百分比在对免疫抑制治疗的临床应答期间随时间推移而降低。这一发现可能表明，CD 14（暗淡）/CD 16（明亮）单核细胞代表了这种极其罕见和高致死性疾病的炎症程度。
Hemophagocytic lymphohistiocytosis (HLH) is an extremely rare and highly lethal chronic inflammatory disease, which is mediated by proinflammatory cytokines. In the peripheral blood of a boy suffering from HLH, a chronic expansion of CDI4(dim)/CD16(bright) inflammatory monocytes was detected. Compared with CD14(bright) monocytes, their immunophenotype correlated with more mature monocytic cells differentiating to macrophages: they showed lower expression of CD11b, CD64 and CD35. Such CD14(dim)/CD16(bright) monocytes produce the inflammatory cytokines IL-1 beta, IL-6 and TNF-alpha. They fit in well with the pathophysiological concept of HLH as an inflammatory state of lymphocytes and of the monocyte/macrophage system. In the presented patient the percentage of these circulating inflammatory monocytes decreased over time during clinical response to immunosuppressive therapy. This finding may indicate that CD14(dim)/CD16(bright) monocytes represented the degree of inflammation in this extremely rare and highly lethal disease.