Regulation of Autophagy Affects the Prognosis of Mice with Severe Acute Pancreatitis.
Regulation of Autophagy Affects the Prognosis of Mice with Severe Acute Pancreatitis.
复制标题
自噬的调节影响重症急性胰腺炎小鼠的预后。
DOI：
10.1007/s10620-018-5053-0
复制
发表时间：
2018
影响因子：
3.1
通讯作者：
Lu Nonghua
中科院分区：
文献类型：
--
作者：
Wan Jianhua;Chen Jie;Wu Dangyan;Yang Xiaoyu;Ouyang Yaobin;Zhu Yin;Xia Liang;Lu Nonghua
BackgroundAcute pancreatitis (AP) is a common inflammatory disease that may develop to severe AP (SAP), resulting in life-threatening complications. Impaired autophagic flux is a characteristic of early AP, and its accumulation could activate oxidative stress and nuclear factor κB (NF-κB) pathways, which aggravate the disease process.AimTo explore the therapeutic effects of regulating autophagy after the onset of AP.MethodsIn this study, intraperitoneal injections of 3-methyladenine (3-MA) and rapamycin (RAPA) in thel-arginine or cerulein plus lipopolysaccharide (LPS) Balb/C mouse model. At 24 h after the last injection, pulmonary, intestinal, renal and pancreatic tissues were analyzed.ResultsWe found that 3-MA ameliorated systemic organ injury in two SAP models. 3-MA treatment impaired autophagic flux and alleviated inflammatory activation by modulating the NF-κB signaling pathway and the caspase-1-IL-1β pathway, thus decreasing the injuries to the organs and the levels of inflammatory cytokines.ConclusionOur study found that the regulation of autophagy could alter the progression of AP induced byl-arginine or cerulein plus LPS in mice.
