Role of sensory-evoked NMDA plateau potentials in the initiation of locomotion
Role of sensory-evoked NMDA plateau potentials in the initiation of locomotion
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DOI：
10.1126/science.278.5340.1122
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发表时间：
1997-11-07
期刊：
影响因子：
56.9
通讯作者：
Dubuc, R
中科院分区：
文献类型：
--
作者：
DiPrisco, GV;Pearlstein, E;Dubuc, R
网状脊髓（RS）神经元构成七鳃鳗的主要下行运动系统。本研究报告了一种自然条件，其中N-甲基-D-天冬氨酸（NMDA）介导的平台电位引起的，并与运动的开始。网状脊髓神经元以线性方式对轻度皮肤刺激作出反应。在较强的刺激下，引起具有尖峰活动的大的去极化平台，并伴有游泳运动。钙成像显示，在感觉刺激下，细胞内钙持续升高。阻断RS神经元上的NMDA受体可防止平台电位以及相关的细胞内钙升高。因此，NMDA受体的激活介导了RS神经元从感觉接收模式到运动命令模式的转换。
Reticulospinal (RS) neurons constitute the main descending motor system of lampreys. This study reports an natural conditions whereby N-methyl-D-aspartate (NMDA)-mediated plateau potentials were elicited and associated with the onset of locomotion. Reticulospinal neurons responded in a linear fashion to mild skin stimulation. With stronger stimuli, large depolarizing plateaus with spiking activity were elicited and were accompanied by swimming movements, Calcium imaging revealed sustained intracellular calcium rise upon sensory stimulation. Blocking NMDA receptors on RS neurons prevented the plateau potentials as well as the associated rise in intracellular calcium. Thus, the activation of NMDA receptors mediates a switch from sensory-reception mode to a motor command mode in RS neurons.