Role of connexin43-interacting proteins at gap junctions
Role of connexin43-interacting proteins at gap junctions
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DOI：
10.1159/000092561
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发表时间：
2006-01-01
期刊：
影响因子：
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通讯作者：
Giepmans, Ben N. G.
中科院分区：
文献类型：
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作者：
Giepmans, Ben N. G.
缝隙连接是细胞间通道的阵列，允许小分子在相邻细胞之间扩散。单个通道由四跨膜连接蛋白（Cx）蛋白形成。最近，已经发现多种蛋白质在胞质位点与最丰富的连接蛋白Cx43相互作用，但关于这些相互作用的作用的生理数据很少。在这里，Cx43相互作用的分子细节和Cx43相互作用蛋白质的假定作用进行了讨论。重点是对c-Src和ZO-1与Cx43相互作用的新见解，在过去2年内发现的相互作用蛋白（dreplant，CIP 85，CCN 3），以及间隙连接，粘附连接（N-钙粘蛋白和连环蛋白）和细胞骨架（微管和肌动蛋白）之间的反馈。版权所有（c）2006 S. Karger AG，巴塞尔。
Gap junctions are arrays of cell-to-cell channels that allow diffusion of small molecules between neighboring cells. The individual channels are formed by the four-transmembrane connexin (Cx) proteins. Recently, multiple proteins have been found to interact at the cytoplasmic site with the most abundant connexin, Cx43, but physiological data about the role of these interactions is scarce. Here, molecular detail about Cx43 interactions is presented and the putative roles of Cx43-interacting proteins are discussed. Emphasis is on new insights into the interactions of c-Src and ZO-1 with Cx43, interacting proteins discovered within the last 2 years (drebrin, CIP85, CCN3), and feedback between gap junctions, adherens junctions (N-cadherin and catenins) and the cytoskeleton (microtubules and actin). Copyright (c) 2006 S. Karger AG, Basel.