Downregulation of prostaglandin E2 is involved in hindgut mucosal damage in lactating goats fed a high‐concentrate diet
Downregulation of prostaglandin E2 is involved in hindgut mucosal damage in lactating goats fed a high‐concentrate diet
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DOI：
10.1113/ep085256
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发表时间：
2015-11
影响因子：
2.7
通讯作者：
S. Tao;Zhengqiang Han;J. Tian;R. Cong;Y. Duanmu;Haibo Dong;Y. Ni;R. Zhao
中科院分区：
文献类型：
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作者：
S. Tao;Zhengqiang Han;J. Tian;R. Cong;Y. Duanmu;Haibo Dong;Y. Ni;R. Zhao
这项研究的中心问题是什么？高浓缩（HC）饮食会导致后肠黏膜的损伤。本研究旨在探讨亚急性瘤胃酸中毒山羊后肠黏膜上皮细胞增殖状况，同时探讨前列腺素E2的合成及其下游信号通路。主要发现是什么及其重要性？局部前列腺素E2合成及其下游信号通路的下调参与了HC喂养山羊后肠上皮细胞增殖抑制的过程。我们的研究结果为后肠异常发酵与肠黏膜屏障损伤之间的关系提供了新的见解。
What is the central question of this study? A high‐concentrate (HC) diet results in damage to the hindgut mucosa. The aim of the study was to investigate the status of epithelial proliferation in the hindgut mucosa of goats with subacute ruminal acidosis and, simultaneously, to evaluate prostaglandin E2 synthesis and the downstream signalling pathways. What is the main finding and its importance? The downregulation of local prostaglandin E2 synthesis and its downstream signalling pathway are involved in the process of inhibiting epithelial proliferation in the hindgut epithelium of HC‐fed goats. Our results provide new insight into the relationship between abnormal fermentation in the hindgut and damage to the intestinal mucosal barrier.