Anti-SARS-CoV immunoglobulin G in healthcare workers, Guangzhou, China
Anti-SARS-CoV immunoglobulin G in healthcare workers, Guangzhou, China
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DOI：
10.3201/eid1101.040138
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发表时间：
2005-01-01
影响因子：
11.8
通讯作者：
Yan, GM
中科院分区：
文献类型：
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作者：
Chen, WQ;Lu, CY;Yan, GM
为确定医务人员隐性感染严重急性呼吸综合征(SARS)的流行情况，我们对2003年5月中旬收治SARS患者的3家医院的1147名医护人员进行了SARS冠状病毒免疫球蛋白G抗体(SARS-CoV)的血清调查。其中包括90名患有SARS的医护人员。作为参考组，在两家从未收治过任何SARS患者的医院工作的709名医护人员接受了类似的测试。SARS医护人员血清阳性率为88.9%(80/90)，健康医护人员血清阳性率为1.4%(15/1057)。对照组血清阳性率为0.4%(3/709)。这些发现表明，隐性感染并不常见。未受影响的医护人员的免疫力水平较低，这加强了医院采取适当的个人保护和其他感染控制措施的必要性，以防止未来的流行病。
To determine the prevalence of inapparent infection with severe acute respiratory syndrome (SARS) among healthcare workers, we performed a serosurvey to test for immunoglobulin (Ig) G antibodies to the SARS coronavirus (SARS-CoV) among 1,147 healthcare workers in 3 hospitals that admitted SARS patients in mid-May 2003. Among them were 90 healthcare workers with SARS. As a reference group, 709 healthcare workers who worked in 2 hospitals that never admitted any SARS patients were similarly tested. The seroprevalence rate was 88.9% (80/90) for healthcare workers with SARS and 1.4% (15/1,057) for healthcare workers who were apparently healthy. The seroprevalence in the reference group was 0.4% (3/709). These findings suggest that inapparent infection is uncommon. Low level of immunity among unaffected healthcare workers reinforces the need for adequate personal protection and other infection control measures in hospitals to prevent future epidemics.