An artificial photosensitizer drug network for mitochondria-selective photodynamic therapy
An artificial photosensitizer drug network for mitochondria-selective photodynamic therapy
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DOI：
10.1039/c2cc16087k
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发表时间：
2012-01-01
影响因子：
4.9
通讯作者：
Lee, Eun Seong
中科院分区：
文献类型：
--
作者：
Park, So Young;Oh, Kyung Taek;Lee, Eun Seong
我们报告了一类新的光敏剂药物网络，它可以定位到线粒体，并为肿瘤提供地理空间光毒性。我们利用光敏剂药物和聚乙二醇之间可切割的化学网络，发现多聚体药物网络在线粒体摄取和肿瘤抑制方面的效率显著提高。
We report a new class of photosensitizer drug networks that can home into mitochondria and provide geospatial phototoxicity for tumors. We take advantage of the cleavable chemical network between the photosensitizer drug and poly(ethylene glycol), and find a significant increase in the efficiency of the multimeric drug network in mitochondria uptake and tumor inhibition.