The role of cholesterol metabolism and cholesterol transport in carcinogenesis: a review of scientific findings, relevant to future cancer therapeutics.
The role of cholesterol metabolism and cholesterol transport in carcinogenesis: a review of scientific findings, relevant to future cancer therapeutics.
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DOI：
10.3389/fphar.2013.00119
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发表时间：
2013-09-25
影响因子：
5.6
通讯作者：
Lacko AG
中科院分区：
文献类型：
--
作者：
Cruz PM;Mo H;McConathy WJ;Sabnis N;Lacko AG
虽然恶性组织作为癌症治疗的潜在靶点的独特代谢活性已成为最近几篇综述的主题，但胆固醇代谢在此背景下的作用尚未得到充分探讨。胆固醇是哺乳动物细胞膜的重要组成部分，也是胆汁酸和类固醇激素的前体。癌细胞需要过量的胆固醇和胆固醇生物合成途径的中间体来维持高水平增殖的假设是公认的，然而恶性细胞和组织重新编程胆固醇合成、摄取和流出的机制尚未被完全阐明为潜在的治疗靶点。高密度和低密度血浆脂蛋白可能是癌细胞和肿瘤胆固醇的主要供应者，可能通过受体介导的机制。本文综述了脂蛋白在肿瘤发生中的作用及其作为肿瘤靶向化疗药物载体的研究进展。
While the unique metabolic activities of malignant tissues as potential targets for cancer therapeutics has been the subject of several recent reviews, the role of cholesterol metabolism in this context is yet to be fully explored. Cholesterol is an essential component of mammalian cell membranes as well as a precursor of bile acids and steroid hormones. The hypothesis that cancer cells need excess cholesterol and intermediates of the cholesterol biosynthesis pathway to maintain a high level of proliferation is well accepted, however the mechanisms by which malignant cells and tissues reprogram cholesterol synthesis, uptake and efflux are yet to be fully elucidated as potential therapeutic targets. High and low density plasma lipoproteins are the likely major suppliers of cholesterol to cancer cells and tumors, potentially via receptor mediated mechanisms. This review is primarily focused on the role(s) of lipoproteins in carcinogenesis, and their future roles as drug delivery vehicles for targeted cancer chemotherapy.
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DOI：
10.1084/jem.20040213
发表时间：
2004-08-02
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Gajate C;Del Canto-Jañez E;Acuña AU;Amat-Guerri F;Geijo E;Santos-Beneit AM;Veldman RJ;Mollinedo F
通讯作者：
Mollinedo F
影响因子：
5.2
作者：
Ginestier, Christophe;Monville, Florence;Charafe-Jauffret, Emmanuelle
通讯作者：
Charafe-Jauffret, Emmanuelle
影响因子：
56.9
作者：
BROWN, MS;GOLDSTEIN, JL
通讯作者：
GOLDSTEIN, JL
DOI：
10.1016/j.bbrc.2009.01.147
发表时间：
2009-03-20
影响因子：
3.1
作者：
Gajate, Consuelo;Gonzalez-Camacho, Fernando;Mollinedo, Faustino
通讯作者：
Mollinedo, Faustino
影响因子：
4
作者：
Dufour, Julie;Viennois, Emilie;Lobaccaro, Jean-Marc
通讯作者：
Lobaccaro, Jean-Marc