Diet or exercise: what is more effective in preventing or reducing metabolic alterations?
Diet or exercise: what is more effective in preventing or reducing metabolic alterations?
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DOI：
10.1530/eje-08-0334
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发表时间：
2008-12-01
影响因子：
5.8
通讯作者：
Pagano, Gianfranco
中科院分区：
文献类型：
--
作者：
Bo, Simona;Ciccone, Giovannino;Pagano, Gianfranco
目的/设计：饮食和运动对代谢综合征的影响是有争议的，因为健康的人可能也会吃更健康的食物。在一项为期1年的随机生活方式干预试验中，我们评估了饮食/运动变化与代谢变量和c反应蛋白（CRP）值降低的关系，该试验是在多发性代谢异常患者中进行的。方法：对生活方式干预后的169例患者和166例对照组进行前瞻性研究。结果：干预组分别有15/169（8.9%）、63/169（37.39%）和70/169（41.4%）达到仅饮食目标、仅运动目标和饮食/运动目标。减轻体重。体重指数（BMI）和腰围只有在增加运动的患者中才有意义。多数对照未达到目标（131/166,78.99%）。少数患者仅达到饮食目标（13/166,7.8%）、运动目标（5/166,3.0%）和饮食/运动目标（17/166,10.2%）。在达到运动目标的人群中，体重、BMI和腰围的减少更为明显。在整个队列中，增加运动与体重、BMI、腰围和CRP呈负相关。饱和脂肪的增加与体重直接相关。BMI，腰围和舒张压变化。而在多元回归模型中，纤维摄入量的增加与血糖值呈负相关。腰部调整后。但运动与CRP （β = -0.023: 95% CI -0.028 -0.017: P < 0.001）以及纤维与葡萄糖（β = -0.022: -0.031 -0.013; P < 0.001）之间的相关性仍然显著。结论：与减肥无关，运动水平和纤维摄入量分别与CRP和空腹血糖值呈负相关。生活方式的改变可以降低炎症，防止代谢恶化。
Objective/design: The influence of diet and exercise on metabolic syndrome is controversial since fit individuals might also cat healthier foods. We evaluated the association of diet/exercise variation with reductions in metabolic variables and C-reactive protein (CRP) values in the experimental and control arms of a 1-year randomized lifestyle intervention trial performed in patients with Multiple metabolic abnormalities.Methods: A prospective study of 169 cases and 166 controls after a lifestyle intervention was performed.Results: In the intervention group, 15/169 (8.9%), 63/169 (37.39%), and 70/169 (41.4%) reached only dietary, only exercise, and dietary/exercise targets respectively. Reductions in weight. body mass index (BMI), and waist were significant only in patients who increased exercise. Most controls did not reach any target (131/166, 78.99%). while only few patients reached only dietary (13/166, 7.8%), only exercise (5/166, 3.0%), and dietary/exercise targets (17/166, 10.2%). Weight, BMI, and waist reduction was more pronounced in those reaching the exercise target. In the whole cohort, increased exercise was inversely associated with weight, BMI, waist, and CRP. increased saturated fat was directly associated with weight. BMI, waist, and diastolic pressure variations. while increased fiber intake was inversely associated with glucose values in a multiple regression model. After adjusting for waist. changes, the associations between exercise and CRP (beta = -0.023: 95% CI -0.028 -0.017: P < 0.001) and the associations between fiber and glucose (beta = -0.022: -0.031 -0.013; P < 0.001) remained significant.Conclusions: Independent of weight reduction, exercise level and fiber intake are inversely associated with CRP and fasting glucose values respectively. Change in lifestyle may lower inflammation and prevent metabolic deterioration.