Nasal cytokine and chemokine responses in experimental influenza A virus infection: Results of a placebo-controlled trial of intravenous zanamivir treatment
Nasal cytokine and chemokine responses in experimental influenza A virus infection: Results of a placebo-controlled trial of intravenous zanamivir treatment
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DOI：
10.1086/314938
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发表时间：
1999-09-01
影响因子：
6.4
通讯作者：
Straus, SE
中科院分区：
文献类型：
--
作者：
Fritz, RS;Hayden, FG;Straus, SE
通过测定15名实验性感染A/Texas 136/91（H1N1）流感的志愿者的连续鼻灌洗液样品中的细胞因子和趋化因子水平来表征对流感病毒感染的局部免疫应答。该研究是确定静脉注射扎那米韦的预防效果的随机双盲安慰剂对照试验的Dart（600 mg 2 x /天，持续5天），一种高度选择性的甲型和B型流感病毒神经氨酸酶抑制剂，对流感感染的临床症状的影响。鼻灌洗液中白细胞介素（IL）-6、肿瘤坏死因子-α、干扰素-γ、IL-10、单核细胞趋化蛋白-1和巨噬细胞炎性蛋白-1 α和-1 β的水平在流感病毒感染后升高，并与症状的严重程度和时间进程统计学相关。扎那米韦治疗预防了感染，并消除了局部细胞因子和趋化因子反应。这些结果揭示了细胞因子和趋化因子在流感症状的发展和消退中的复杂相互作用。
The local immune response to influenza virus infection was characterized by determining cytokine and chemokine levels in serial nasal lavage fluid samples from 15 volunteers experimentally infected with influenza A/Texas136/91 (H1N1), The study was Dart of a randomized double-blind placebo-controlled trial to determine the prophylactic effect of intravenous zanamivir (600 mg 2 x /day for 5 days), a highly selective inhibitor of influenza A and B virus neuraminidases, on the clinical symptoms of influenza infection. Nasal lavage fluid levels of interleukin (IL)-6, tumor necrosis factor-alpha, interferon-gamma, IL-10, monocyte chemotactic protein-1, and macrophage inflammatory protein-1 alpha and -1 beta increased in response to influenza virus infection and correlated statistically with the magnitude and time course of the symptoms. Treatment with zanamivir prevented the infection and abrogated the local cytokine and chemokine responses. These results reveal a complex interplay of cytokines and chemokines in the development of symptoms and resolution of influenza.