Mimicry of CD40 signals by Epstein-Barr virus LMP1 in B lymphocyte responses
Mimicry of CD40 signals by Epstein-Barr virus LMP1 in B lymphocyte responses
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DOI：
10.1126/science.286.5438.300
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发表时间：
1999-10-08
期刊：
影响因子：
56.9
通讯作者：
Kikutani, H
中科院分区：
文献类型：
--
作者：
Uchida, J;Yasui, T;Kikutani, H
研究了EB病毒潜伏膜蛋白1（LMP 1）对正常B细胞活化和分化的影响。在免疫球蛋白启动子/增强子控制下表达LMP 1的转基因小鼠的B细胞显示活化抗原的表达增强，并自发增殖和产生抗体。在CD 40缺陷或正常背景下的LMP 1转基因小鼠的体液免疫应答显示，LMP 1模拟CD 40信号诱导滤泡外13细胞分化，但与CD 40不同，LMP 1阻断生发中心形成。因此，LMP 1的这些特异性可能决定了原发性B细胞感染的位点和EBV感染的自然过程中的感染状态，而随后LMP 1表达的丧失可能影响持续潜伏感染的位点。
The effect of the Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) on the activation and differentiation of normal B cells was investigated. B cells of transgenic mice expressing LMP1 under the control of immunoglobulin promoter/enhancer displayed enhanced expression of activation antigens and spontaneously proliferated and produced antibody. Humoral immune responses of LMP1 transgenic mice in CD40-deficient or normal backgrounds revealed that LMP1 mimics CD40 signals to induce extrafollicular 13 cell differentiation but, unlike CD40, blocks germinal center formation. Thus, these specific properties of LMP1 may determine the site of primary B cell infection and the state of infection in the natural course of EBV infection, whereas subsequent loss of LMP1 expression may affect the site of persistent latent infection.