Development of Circularly Polarized Luminescence (CPL) Peptides Containing Pyrenylalanines and 2-Aminoisobutyric Acid
Development of Circularly Polarized Luminescence (CPL) Peptides Containing Pyrenylalanines and 2-Aminoisobutyric Acid
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DOI：
10.3390/pr8121550
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发表时间：
2020-11
期刊：
影响因子：
3.5
通讯作者：
Y. Mimura;Yukihisa Motomura;Mizuki Kitamatsu;Y. Imai
中科院分区：
文献类型：
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作者：
Y. Mimura;Yukihisa Motomura;Mizuki Kitamatsu;Y. Imai
手性有机和有机金属发光体在近紫外区和近红外区具有圆偏振发光(CPL)性质，具有很好的应用前景。然而，CPL的性质受化合物的内在因素的影响，到目前为止，关于氨基酸和多肽对CPL性质的影响的研究还很少。因此，我们开发了具有不同CPL性质的多肽-芘有机发光体。可以想象的是，当多肽-芘有机发光体溶解在溶液中时，可以得到聚集体。聚集体的形成也可能使准确检测多肽在溶液中的CPL变得困难。这项研究表明，在多肽骨架中引入空间受阻的2-氨基异丁酸(AIB)单元会抑制聚集体的形成。由于芘单元的存在，所得到的发光体具有CPL性质。这项研究的结果可以为未来使用多肽-芘有机发光体的材料的设计提供基础。
Chiral organic and organometallic luminophores that possess circularly polarized luminescence (CPL) properties in the near-ultraviolet to near-infrared region have several useful applications. However, the CPL properties are subject to inherent factors of the compounds; to date, studies on the CPL properties influenced by amino acids and peptides are scarce. Consequently, we developed peptide-pyrene organic luminophores exhibiting various CPL properties. It is conceivable that the peptide-pyrene organic luminophores can be obtained as aggregates when dissolved in a solution. It is also possible that the formation of aggregates makes it difficult to accurately examine the CPL of the peptide in the solution. This study showed that the introduction of sterically hindered 2-aminoisobutyric acid (Aib) units into the peptide backbone inhibits aggregate formation. The resulting luminophores exhibit CPL properties owing to the presence of pyrene units. The results of this study can form a basis for the design of future materials that use peptide-pyrene organic luminophores.