Prevalence and incidence of comorbidities in elderly women with ovarian cancer
Prevalence and incidence of comorbidities in elderly women with ovarian cancer
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DOI：
10.1016/j.ygyno.2013.02.014
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发表时间：
2013-05-01
影响因子：
4.7
通讯作者：
Griffiths, Robert I.
中科院分区：
文献类型：
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作者：
Chia, Victoria M.;O'Malley, Cynthia D.;Griffiths, Robert I.
目标。研究表明，共病在卵巢癌中起着重要作用。我们描述了患有卵巢癌的老年美国妇女的并存情况的流行病学特征。通过国家癌症研究所的监测、流行病学和与医疗保险索赔相关的最终结果登记，确定了年龄为66岁的卵巢癌女性，并与未患癌症的女性相匹配。对34种慢性和急性疾病在诊断/指数日期之前的患病率和诊断/指数日期后3个月和12个月的发病率(每1000人年)进行了评估。患有卵巢癌的女性和未患癌症的女性各有5087人。癌症患者和非癌症患者的大多数疾病的患病率相似，但例外情况是高血压(分别为51.8%和43.5%)、骨关节炎(分别为13.4%和17.3%)和脑血管疾病(分别为8.0%和9.8%)。相反，癌症患者的3个月和12个月发病率(每千人年)显著高于非癌症患者：高血压(分别为177.3和47.4)；血栓事件(分别为145.3和5.5)；充血性心力衰竭(分别为113.3和2 8.6)；感染(分别为664.4和5 5.2)；贫血(分别为408.3和33.1)。合并症在老年妇女中很常见。在癌症诊断后，患有卵巢癌的女性比未患癌症的女性有更高的合并症发生率。其中一些合并症的高发病率可能与癌症或其治疗有关，但另一些可能已经很普遍，但在癌症诊断之前没有被诊断出来。合并症的存在可能会影响治疗决定。(C)2013 Elsevier Inc.保留所有权利。
Objective. Studies suggest comorbidity plays an important role in ovarian cancer. We characterized the epidemiology of comorbid conditions in elderly U.S. women with ovarian cancer.Methods. Women with ovarian cancer age >= 66 years, and matched cancer-free women, were identified using the National Cancer Institute's Surveillance, Epidemiology, and End Results registry linked to Medicare claims. Prevalence before diagnosis/index date and 3- and 12-month incidence rates (per 1000 person-years) after diagnosis/index date were estimated for 34 chronic and acute conditions across a broad range of diagnostic categories.Results. There were 5087 each of women with ovarian cancer and cancer-free women. The prevalence of most conditions was similar between cancer and cancer-free patients, but exceptions included hypertension (51.8% and 43.5%, respectively), osteoarthritis (13.4% and 17.3%, respectively), and cerebrovascular disease (8.0% and 9.8%, respectively). In contrast, 3- and 12-month incidence rates (per 1000 person years) of most conditions were significantly higher in cancer than in cancer-free patients: hypertension (177.3 and 47.4, respectively); thromboembolic event (145.3 and 5.5, respectively); congestive heart failure (113.3 and 28.6, respectively); infection (664.4 and 55.2, respectively); and anemia (408.3 and 33.1, respectively) at 12 months.Conclusions. Comorbidities were common among elderly women. After cancer diagnosis, women with ovarian cancer had a much higher incidence of comorbidities than cancer-free women. The high incidence of some of these comorbidities may be related to the cancer or its treatment, but others may have been prevalent but undiagnosed until the cancer diagnosis. The presence of comorbidities may affect treatment decisions. (C) 2013 Elsevier Inc. All rights reserved.