Initiation of gonadotropin-releasing hormone antagonist on day 1 as compared to day 6 of stimulation:: Effect on hormonal levels and follicular development in in vitro fertilization cycles
Initiation of gonadotropin-releasing hormone antagonist on day 1 as compared to day 6 of stimulation:: Effect on hormonal levels and follicular development in in vitro fertilization cycles
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DOI：
10.1210/jc.2003-030805
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发表时间：
2003-12-01
影响因子：
5.8
通讯作者：
Devroey, P
中科院分区：
文献类型：
--
作者：
Kolibianakis, EM;Albano, C;Devroey, P
本研究的目的是评估改变GnRH拮抗剂起始时间对体外受精周期中激素环境和卵泡发育的影响。60名接受体外受精的妇女参加了一项前瞻性随机对照试验。患者在周期的第2天开始接受固定剂量的200 IU重组FSH刺激，并在刺激的第1天（n = 30）或第6天（n = 30）开始使用GnRH拮抗剂。与使用拮抗剂的d-6组相比，在卵泡期，d-1组的LH （P< 0.001）和雌二醇（P< 0.001）暴露量显著降低。两组在刺激第6天或人绒毛膜促性腺激素使用当天的卵泡发育均无差异。此外，两组之间的受精率、着床率和每次移植的持续妊娠率相似。总之，在刺激的第1天（与第6天相比）给予GnRH拮抗剂与较低的黄体生成素和雌二醇暴露有关，这似乎不影响卵泡发育。
The objective of the present study was to assess the effect of altering the timing of GnRH antagonist initiation on the hormonal environment and follicular development in in vitro fertilization cycles. Sixty women undergoing in vitro fertilization participated in a prospective randomized controlled trial. Patients were stimulated with a fixed dose of 200 IU recombinant FSH, starting on d 2 of the cycle, and with GnRH antagonist, starting either on d 1 (n = 30) or on d 6 of stimulation (n = 30). A significantly lower exposure to LH (P< 0.001) and estradiol ( P < 0.001) during the follicular phase was observed in the d-1 group, compared with the d-6 group of antagonist administration. No differences in follicular development were seen between the two groups on either d 6 of stimulation or on the day of human chorionic gonadotropin administration. Similar fertilization rates, implantation rates, and ongoing pregnancy rates per transfer were, in addition, present between the two groups compared. In conclusion, administration of GnRH antagonist on d 1 ( compared with d 6) of stimulation is associated with a lower exposure to LH and estradiol, which does not seem to affect follicular development.