Claustral structural connectivity and cognitive impairment in drug naive Parkinson's disease
Claustral structural connectivity and cognitive impairment in drug naive Parkinson's disease
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DOI：
10.1007/s11682-018-9907-z
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发表时间：
2019-08-01
影响因子：
3.2
通讯作者：
Quartarone, Angelo
中科院分区：
文献类型：
--
作者：
Arrigo, Alessandro;Calamuneri, Alessandro;Quartarone, Angelo
屏状体是一个薄的灰质结构，涉及广泛的大脑网络。先前的研究表明屏状核和帕金森病（PD）之间的联系，显示了α-突触核蛋白病理学如何影响屏状核神经元，以及α-突触核蛋白免疫反应性如何与认知功能障碍的发作相关。我们的目的是调查，通过扩散MRI，在药物初治PD患者的claudral结构网络的变化，目的是了解这种变化是否可能有助于认知功能下降的PD。入组了15名药物初治PD患者和15名年龄匹配的对照;在3 T扫描仪上进行MR方案。采用约束球面反卷积（CSD）扩散模型获得全脑概率纤维束成像。连接矩阵估计的基础上一个强大的解剖结构T1 w图像的分割。在PD组中，受损的子网络与心理检查相关。我们发现PD患者与对照组相比，尤其是主要涉及视觉和注意力系统的区域的闭合连接减少。此外，我们发现莫卡与同侧屏状核与左侧（r=0.578，p=0.021）和右侧（r=0.640，p=0.020）眶部连接的通路密度呈正相关。我们的研究结果支持这一假设，即首次用药的PD患者的认知功能下降与幽闭有关。
The claustrum is a thin grey matter structure which is involved in a wide brain network. Previous studies suggested a link between claustrum and Parkinson's Disease (PD), showing how alpha-synuclein pathology may affect claustral neurons as well as how alpha-synuclein immunoreactivity may correlate with the onset of cognitive dysfunctions. Our aim is to investigate, via diffusion MRI, claustral structural network changes in drug naive PD patients, with the goal to understand whether such changes may contribute to cognitive decline in PD. 15 drug naive PD patients and 15 age-matched controls were enrolled; MR protocol was performed on a 3T scanner. Whole brain probabilistic tractography was obtained using Constrained Spherical Deconvolution (CSD) diffusion model. Connectivity matrices were estimated based on a robust anatomical parcellation of structural T1w images. In PD group, impaired subnetworks were correlated with psychological examinations. We found decreased claustral connectivity in PD patients compared to controls, especially with areas mainly involved in visuomotor and attentional systems. Moreover, we found a positive correlation between MoCA and density of pathways connecting ipsilaterally claustrum to left (r=0.578, p=0.021) and right (r=0.640, p=0.020) Pars Orbitalis. Our results support the hypothesis of claustral involvement in cognitive decline in drug naive PD patients.