Cognitive Function and Social Attainment in Adult Survivors of Retinoblastoma: A Report from the St. Jude Lifetime Cohort Study
Cognitive Function and Social Attainment in Adult Survivors of Retinoblastoma: A Report from the St. Jude Lifetime Cohort Study
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DOI：
10.1002/cncr.28924
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发表时间：
2015-01-01
期刊：
影响因子：
6.2
通讯作者：
Krull, Kevin R.
中科院分区：
文献类型：
--
作者：
Brinkman, Tara M.;Merchant, Thomas E.;Krull, Kevin R.
BACKGROUNDRetinoblastoma has a 5-year survival rate exceeding 95%, yet little is known about long-term functional outcomes for these patients.METHODSSixty-nine adult survivors of retinoblastoma (mean age, 33 years; mean years post-diagnosis, 31) who had enrolled in the St. Jude Lifetime Cohort Study completed clinical cognitive evaluations and questionnaires assessing adult social attainment. Scores on all cognitive measures were converted to z-scores (M=0, SD=1) using age-adjusted normative data. Multivariable linear regression analyses, adjusted for age at diagnosis and disease laterality, were used to examine associations between disease and treatment exposures and cognitive outcomes.RESULTSRetinoblastoma survivors performed within normative expectations across most cognitive domains. In multivariable models, adjusted for disease laterality, survivors diagnosed at 1 year of age performed significantly better on measures of short-term verbal memory (=0.87, P
