Acquired tetracycline and/or macrolide-lincosamides-streptogramin resistance in anaerobes
Acquired tetracycline and/or macrolide-lincosamides-streptogramin resistance in anaerobes
复制标题
DOI：
10.1016/s1075-9964(03)00058-1
复制
发表时间：
2003-04-01
期刊：
影响因子：
2.3
通讯作者：
Roberts, MC
中科院分区：
文献类型：
--
作者：
Roberts, MC
一般来说，细菌对抗生素的耐药性是在可移动的元件上获得的，如质粒、转座子和/或接合转座子。文献中描述的许多耐抗生素厌氧菌也是如此。在已鉴定的23种不同的四环素耐药外排基因中，tet(B)、tet(K)、tet(L)和tea(P)已在厌氧菌中发现，而编码核糖体保护蛋白的10个四环素耐药基因中的6个已在厌氧菌中发现，即tet(M)、tet(O)、teB(P)、tet(Q)、tet(W)和tet(32)。目前有三种酶可使四环素失活，其中tet(X)已在类杆菌中被鉴定，但在厌氧生长条件下不起作用。类似的情况也存在于与大环内酯-林可酰胺-链菌素(MLS)耐药相关的基因上。在已鉴定的26个rRNA甲基化酶MLS耐药基因中，已在厌氧菌中鉴定出erm(B)、erm(C)、erm(F)、erm(G)和erm(Q)5个基因。相比之下，在厌氧物种中没有编码NILS抗性外排蛋白或失活酶的基因。本文将对四环素和MLS耐药在厌氧菌属中的已知情况以及与获得性四环素和/或MLS耐药基因相关的可移动元件进行综述。(C)2003爱思唯尔科学有限公司。保留所有权利。
In general bacterial antibiotic resistance is acquired on mobile elements such as plasmids, transposons and/or conjugative transposons. This is also true for many antibiotic resistant anaerobic species described in the literature. Of the 23 different tetracycline resistant efflux genes identified, tet(B), tet(K), tet(L), and tetA(P) have been found in anaerobic species and six of the ten tetracycline resistant genes coding for ribosomal protection proteins, tet(M), tet(O), tetB(P), tet(Q), tet(W), and tet(32), have been identified in anaerobes. There are now three enzymes which inactivate tetracycline, of which the tet(X) has been identified in Bacteroides though is not functional under anaerobic growth conditions. A similar situation exists with the genes conferring macrolide-lincosamide-streptogramin (MLS) resistance. Of the 26 rRNA methylase MLS resistant genes characterized, five genes; erm(B), erm(C), erm(F), erm(G), and erm(Q), have been identified in anaerobes. In contrast, no genes coding for NILS resistant efflux proteins or inactivating enzymes have been described in anaerobic species. This mini-review will summarize what is known about tetracycline and MLS resistance in genera with anaerobic species and the mobile elements associated with acquired tetracycline and/or MLS resistance genes. (C) 2003 Elsevier Science Ltd. All rights reserved.