Cytokines and depression: fortuitous or causative association?
Cytokines and depression: fortuitous or causative association?
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DOI：
10.1038/sj.mp.4000572
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发表时间：
1999-07-01
影响因子：
11
通讯作者：
Yirmiya, R
中科院分区：
文献类型：
--
作者：
Dantzer, R;Wollman, E;Yirmiya, R
有一个越来越令人印象深刻的数据库，关于细胞因子在抑郁症中的可能参与以及它们在抗抑郁药治疗效果中的作用。根据最近在法国罗斯科夫举行的一次会议上对这些问题的讨论，这种观点以批判的方式总结了支持这种可能性的证据，并指出需要进一步研究来澄清影响抑郁症神经内分泌免疫相互作用的微妙失调的性质及其对精神病理学的贡献。
There is an increasingly impressive database concerning the possible involvement of cytokines in depression and their role in the therapeutic effects of antidepressants. Based on the discussions which took place on these issues at a recent meeting held in Roscoff, France, this perspective summarizes in a critical way the evidence in favor of such a possibility, and points out the needs for further research to clarify both the nature of the subtle dysregulations that affect neuroendocrine-immune interactions in depressive disorders and their contribution to psychopathology.