Acupuncture-induced changes in functional connectivity of the primary somatosensory cortex varied with pathological stages of Bell's palsy.
Acupuncture-induced changes in functional connectivity of the primary somatosensory cortex varied with pathological stages of Bell's palsy.
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DOI：
10.1097/wnr.0000000000000246
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发表时间：
2014-10-01
期刊：
影响因子：
1.7
通讯作者：
Qiu B
中科院分区：
文献类型：
--
作者：
He X;Zhu Y;Li C;Park K;Mohamed AZ;Wu H;Xu C;Zhang W;Wang L;Yang J;Qiu B
贝尔氏麻痹是急性面神经麻痹最常见的原因。在中国，贝尔氏麻痹经常用针灸治疗。然而，其有效性和潜在机制仍存在争议。在这项研究中，我们使用功能性磁共振成像研究针刺对贝尔麻痹患者和健康人大脑功能连接的影响。根据病程和面部运动表现对患者进行进一步分组。静息态功能磁共振连接的结果表明，针刺引起早期和晚期恢复组的初级躯体感觉区的连接发生显著变化，而健康对照组和恢复组的连接均无显著变化。在恢复组中，变化也因地区和疾病持续时间而异。因此，我们提出针刺刺激的效果可能取决于贝尔麻痹患者的功能连接状态。
Bell’s palsy is the most common cause of acute facial nerve paralysis. In China, Bell’s palsy is frequently treated with acupuncture. However, its efficacy and underlying mechanism are still controversial. In this study, we used functional MRI to investigate the effect of acupuncture on the functional connectivity of the brain in Bell’s palsy patients and healthy individuals. The patients were further grouped according to disease duration and facial motor performance. The results of resting-state functional MRI connectivity show that acupuncture induces significant connectivity changes in the primary somatosensory region of both early and late recovery groups, but no significant changes in either the healthy control group or the recovered group. In the recovery group, the changes also varied with regions and disease duration. Therefore, we propose that the effect of acupuncture stimulation may depend on the functional connectivity status of patients with Bell’s palsy.