Role of European mitochondrial DNA haplogroups in the prevalence of hip osteoarthritis in Galicia, Northern Spain
Role of European mitochondrial DNA haplogroups in the prevalence of hip osteoarthritis in Galicia, Northern Spain
复制标题
DOI：
10.1136/ard.2008.105254
复制
发表时间：
2010-01-01
影响因子：
27.4
通讯作者：
Blanco, F. J.
中科院分区：
文献类型：
--
作者：
Rego, I.;Fernandez-Moreno, M.;Blanco, F. J.
目的：分析线粒体DNA（mtDNA）单倍型组的髋关节骨关节炎（OA）患者和健康对照组在西班牙population.Methods：mtDNA单倍型组被分配到550例髋关节OA和505例临床无症状对照。健康的膝关节和髋关节（n = 179）和膝关节和/或髋关节OA患者（n = 977）的对照组也进行了分析，在调整性别，年龄和吸烟后的多变量analysis。结果：携带单倍型J的个人显示出显着降低风险发展髋关节OA（OR 0.661; 95%CI 0.440至0.993; p = 0.045）。除了单倍群J外，吸烟可预防髋关节OA的发生（OR 0.543; 95%CI 0.311 - 0.946; p = 0.031）。然而，没有发现类风湿关节炎和mtDNA单倍型groups.Conclusion之间的关系：本研究的结果支持的假设，mtDNA单倍型groups. In复杂的骨关节炎的过程中发挥了作用。
Objective: To analyse the mitochondrial DNA (mtDNA) haplogroups of patients with hip osteoarthritis (OA) and those of healthy controls in a Spanish population.Methods: mtDNA haplogroups were assigned to 550 cases of hip OA and 505 clinically asymptomatic controls. Sets of controls with healthy knees and hips (n = 179) and patients with knee and/or hip OA (n = 977) were also analysed in a multivariate analysis after adjusting for sex, age and smoking.Results: Individuals carrying haplogroup J showed a significantly decreased risk of developing hip OA (OR 0.661; 95% CI 0.440 to 0.993; p = 0.045). In addition to haplogroup J, smoking protected against the development of hip OA (OR 0.543; 95% CI 0.311 to 0.946; p = 0.031). However, no relationship was found between rheumatoid arthritis and mtDNA haplogroups.Conclusion: The results of this study support the hypothesis that the mtDNA haplogroups have a role in the complex osteoarthritic process.