The dynamics of cancer stem cells
The dynamics of cancer stem cells
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DOI：
10.4149/neo_2012_092
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发表时间：
2012-01-01
期刊：
影响因子：
3
通讯作者：
Hatina, J.
中科院分区：
文献类型：
--
作者：
Hatina, J.
随着肿瘤细胞组织的分层模型的形成，癌症干细胞来到了癌症生物学的前沿。作为唯一的自我更新肿瘤细胞，它们负责肿瘤的持续生长，并且它们内在的自我保护能力被认为是癌症治疗抗性和/或复发的基础。迁移性癌症干细胞的概念将分级癌细胞模型的相关性扩展到癌症进展的问题，通过证明上皮间充质转化可以传递干性提供了关键的实验证据。因此，癌干细胞可能代表了一个高度动态的细胞群，它们分别通过间充质上皮转化和上皮间充质转化等过程不断分化和不断补充。因此，从治疗靶向的角度来看，癌症干细胞显然不再代表固定的靶群体。因此，了解癌症干细胞的动态性质不仅对我们理解基本癌症生物学的进展至关重要，而且从治疗的角度来看也是如此。
With the formulation of the hierarchical model of tumor cell organization, cancer stem cells came to the forefront of cancer biology. As the only self-renewing tumor cells, they were made responsible for continuous tumor growth and their intrinsic self-protection ability was postulated to underlie cancer therapy resistance and/or recurrence. The concept of migrating cancer stem cells extended the relevance of the hierarchical cancer cell model to issue of cancer progression, with the crucial experimental evidence being provided by the demonstration that epithelial mesenchymal transition can convey sternness. Accordingly, cancer stern cells probably represent a highly dynamic cell population continuously differentiating and being continuously replenished by processes like mesenchymal epithelial transition and epithelial mesenchymal transition, respectively. Consequently, from the point of view of therapeutic targeting, cancer stem cells obviously do not represent a fixed target population any longer. Understanding the dynamic nature of cancer stem cells is thus essential not only for the progress in our understanding of basic cancer biology, but also from the therapeutic perspective.