Behavioral and psychological symptoms in Alzheimer's disease: Frequency and relationship with duration and severity of the disease
Behavioral and psychological symptoms in Alzheimer's disease: Frequency and relationship with duration and severity of the disease
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DOI：
10.1159/000084552
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发表时间：
2005-01-01
影响因子：
2.4
通讯作者：
Inzitari, D
中科院分区：
文献类型：
--
作者：
Piccininni, M;Di Carlo, A;Inzitari, D
痴呆症（BPSD）的行为和心理症状的发生目前被认为是阿尔茨海默病（AD）的一个重要方面。我们使用神经精神病学调查表评估了 50 名连续 AD 门诊患者的不同程度和阶段的 BPSD 频率和严重程度。冷漠、异常的运动活动、烦躁和焦虑是护理人员最常报告的症状，在整个研究样本中的比例为 46% 至 74%。随着疾病严重程度的增加，妄想、幻觉和异常运动活动的频率呈明显增加的趋势。疾病持续时间的主要影响是出现幻觉和异常运动活动的可能性。除了幻觉外，所有 BPSD 都是从轻度痴呆开始出现的。为了改善痴呆症治疗的卫生资源分配，有必要更好地了解 AD 中 BPSD 的全球范围。版权所有 (C) 2005 S. Karger AG，巴塞尔。
The occurrence of behavioral and psychological symptoms of dementia (BPSD) is currently recognized as an important aspect of Alzheimer's disease (AD). We evaluated the frequency and severity of BPSD with the Neuropsychiatric Inventory across the various degrees and phases of the disease in 50 consecutive AD outpatients. Apathy, aberrant motor activity, dysphoria and anxiety were the symptoms most frequently reported by the caregivers, ranging in the whole study sample from 46 to 74%. A clear trend towards increasing frequency with the severity of disease was found for delusions, hallucinations and aberrant motor activity. A major effect of the duration of the disease was found in the probability of developing hallucinations and aberrant motor activity. Apart from hallucinations, all BPSD were present starting from a mild degree of dementia. A better understanding of the global spectrum of BPSD in AD is warranted in order to improve the allocation of health resources toward the treatment of dementia. Copyright (C) 2005 S. Karger AG, Basel.