Difference between evolutionarily effective and germ line mutation rate due to stochastically varying haplogroup size
Difference between evolutionarily effective and germ line mutation rate due to stochastically varying haplogroup size
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DOI：
10.1093/molbev/msl105
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发表时间：
2006-12-01
影响因子：
10.7
通讯作者：
Feldman, Marcus W.
中科院分区：
文献类型：
--
作者：
Zhivotovsky, Lev A.;Underhill, Peter A.;Feldman, Marcus W.
在由独特的事件突变定义的Y染色体单倍群中，由于微卫星的快速突变，微卫星的变异可能会累积。根据家系对Y染色体微卫星突变率的估计比从进化角度进行的相同估计高出3倍或更多。我们通过模拟表明，在漂移和灭绝的随机过程中幸存下来的单倍群累积微卫星变异的速度比相应的系谱估计预测的要低；特别是在总种群规模不变的情况下，累积方差平均小3-4倍。
Within a Y-chromosome haplogroup defined by unique event mutations, variation in microsatellites can accumulate due to their rapid mutation. Estimates based on pedigrees for the Y-chromosome microsatellite mutation rate are 3 or more times greater than the same estimates from evolutionary considerations. We show by simulation that the haplogroups that survive the stochastic processes of drift and extinction accumulate microsatellite variation at a lower rate than predicted from corresponding pedigree estimates; in particular, under constant total population size, the accumulated variance is on average 3-4 times smaller.