LYOPHILIZED GLUTARALDEHYDE-PRESERVED BOVINE PERICARDIUM FOR EXPERIMENTAL ATRIAL SEPTAL DEFECT CLOSURE
LYOPHILIZED GLUTARALDEHYDE-PRESERVED BOVINE PERICARDIUM FOR EXPERIMENTAL ATRIAL SEPTAL DEFECT CLOSURE
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DOI：
10.22203/ecm.v019a16
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发表时间：
2010-01-01
影响因子：
3.1
通讯作者：
Villalba-Caloca, Jaime
中科院分区：
文献类型：
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作者：
Alfredo Santibanez-Salgado, J.;Raul Olmos-Zuniga, J.;Villalba-Caloca, Jaime
各种补片材料已被用于封堵大型房间隔缺损(ASD)。最常用的是自体心包和戊二醛保存的牛心包。冷冻干燥的牛心包还没有在心血管系统内进行测试。本工作的目的是研究冷冻干燥的戊二醛保存的牛心包在ASD闭合中的行为和效果。对16只杂种犬进行了手术。造成直径3 cm的房间隔缺损，用冻干戊二醛保存的牛心包(LGPBP)封闭。II组(n=8)：涤纶补片。对动物进行临床、超声心动图、宏观和微观评估。统计分析采用方差分析(ANOVA)和t检验。所有动物均存活于手术过程和研究时间(6个月)。临床上，所有动物都表现出正常的体力活动，并有正常的心音。超声心动图显示两组患者心脏正常，无心内分流，无血栓形成，无植物生长。大体观察显示，冻干生物假体与涤纶贴片结合良好。I组动物左心房房间隔缺损面积均较正常对照组明显缩小(P
A variety of patch materials has been used to close large atrial septal defects (ASD). Autologous pericardium and glutaraldehyde-preserved bovine pericardium are the most used. Lyophilized bovine pericardium has not been tested inside the cardiovascular system. The aim of this work was to study the behaviour and effectiveness of lyophilized glutaraldehyde-preserved bovine pericardium in ASD closure. Sixteen mongrel dogs were operated on. A 3 cm diameter atrial septal defect was created, and closed with: Group I (n=8): Lyophilized glutaraldehyde preserved bovine pericardium (LGPBP). Group II (n=8): Vascular Dacron patch. The animals were evaluated clinically, by echocardiography, macroscopically, and microscopically. Statistical analysis was done with analysis of variance (ANOVA) and Student's t-test. All the animals survived the surgical procedure and study time (6 months). Clinically all the animals displayed normal physical activity, with normal cardiac sounds. Echocardiography showed that both groups had a normal heart without intracardiac shunts, no thrombus formation, and no vegetations. Macroscopically all the animals showed good integration of the lyophilized bioprosthesis and Dacron patch. All group I animals presented a decrease of the area of the ASD in the left atrium (p