High CENPM mRNA expression and its prognostic significance in hepatocellular carcinoma: a study based on data mining
High CENPM mRNA expression and its prognostic significance in hepatocellular carcinoma: a study based on data mining
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DOI：
10.1186/s12935-020-01499-y
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发表时间：
2020-08-26
影响因子：
5.8
通讯作者：
Yang, Dong-liang
中科院分区：
文献类型：
--
作者：
Wu, Zeng-hong;Yang, Dong-liang
Background: Hepatocellular carcinoma (HCC) is a high mortality disease, the fifth most general cancer worldwide, and the second leading to cancer-related deaths, with more than 500,000 new patients diagnosed each year. First, the high expression of centromere M (CENPM)in mammary gland tissue of b-catenin transformed mice was identified.Materials and methods: In our study, we evaluated the expression ofCENPMin hepatocellular carcinoma based on data obtained from an online database. Multivariate analysis showed that the expression of CENPM and M classification was an independent prognostic factor for patients with hepatocellular carcinoma.Results: Survival analysis showed that patients with highCENPMhad a worse prognosis than patients with low CENPM(P < 0.01). A multivariate Cox regression hazard model showed that B cells, CD8+ T cells, macrophages, and dendritic cells infiltrated by immune cells were statistically significant in liver cancer (P < 0.05). Using the network, the 50 most frequently changed neighbor genes of CENPM were shown, and the most common change wasRAD21(18.3%).Conclusion: Our study found that the expression ofCENPMwas significantly increased in patients with hepatocellular carcinoma, and it was related to a variety of clinical characteristics, its correlation with the level of immune infiltration and poor prognosis, soCENPMcan be used as a useful prognosis for patients' markers and HCC.
