Locomotor inhibition induced by procaine injections into the nucleus accumbens core, but not the medial ventral striatum: Implication for cocaine-induced locomotion
Locomotor inhibition induced by procaine injections into the nucleus accumbens core, but not the medial ventral striatum: Implication for cocaine-induced locomotion
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DOI：
10.1002/syn.10151
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发表时间：
2003-02-01
期刊：
影响因子：
2.3
通讯作者：
Witkin, BM
中科院分区：
文献类型：
--
作者：
Ikemoto, S;Witkin, BM
我们研究了是否局部麻醉普鲁卡因注射到延髓核核心破坏运动更容易比那些到内侧腹侧纹状体。自发运动减少，在第一个10分钟后立即注射普鲁卡因到核心。当普鲁卡因与D-苯丙胺共同管理的核心，注射也减少了安非他明诱导的运动在最初的10分钟。另一方面，自发或安非他明诱导的运动没有检测到的效果时，普鲁卡因被注射到内侧腹侧纹状体，包括内侧壳和内侧嗅结节。我们重复了我们最近的发现，即可卡因注射到核心诱导延迟，适度的运动，而可卡因注射到内侧腹侧纹状体诱导立即，剧烈的运动。注射安非他明到核心诱导同样有力的运动，内侧腹侧纹状体。这些结果表明，参与运动的核心神经元比内侧腹侧纹状体的神经元更容易受到局部麻醉的影响。换句话说，当可卡因应用于核心时，在内侧腹侧纹状体中诱导剧烈运动的剂量诱导局部麻醉。
We examined whether injections of the local anesthesia procaine into the nucleus accumbens core disrupts locomotion more readily than those into the medial ventral striatum. Spontaneous locomotion decreased during the first 10 min immediately following injections of procaine into the core. When procaine was co-administered with d-amphetamine into the core, the injections also decreased amphetamine-induced locomotion during the initial 10 min. On the other hand, no detectable effect on spontaneous or amphetamine-induced locomotion was found when procaine was injected into the medial ventral striatum, including the medial shell and medial olfactory tubercle. We replicated our recent finding that cocaine injections into the core induced delayed, modest locomotion, while cocaine injections into the medial ventral striatum induced immediate, vigorous locomotion. Injections of amphetamine into the core induced as equally vigorous locomotion as that of the medial ventral striatum. These results show that the neurons of the core involved in locomotion are more vulnerable to local anesthesia than the neurons of the medial ventral striatum. In other words, cocaine at the doses inducing vigorous locomotion in the medial ventral striatum induces local anesthesia when applied to the core.